ArticlePsychological medicine2021
Reduced influence of perceptual context in schizophrenia: behavioral and neurophysiological evidence.
Article in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Atypical Use of Visuospatial Context in Psychotic Psychopathology: A Meta-analysis.Schizophrenia bulletin · 2025Pooled it
- Enhanced visual contrast suppression during peak psilocybin effects: Psychophysical results from a pilot randomized controlled trial.Journal of vision · 2024Trial
- Visual suppression deficits as a biomarker of working memory impairment in schizophrenia.Schizophrenia research. Cognition · 2026Review
- Impaired Contour Object Perception in Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Altered Use of Context During Visual Perception in Psychotic Psychopathology: A Neurophysiological Investigation of Tuned and Untuned Suppression During Contrast Perception.Schizophrenia bulletin · 2024Article
- Impaired contour object perception in psychosis.medRxiv : the preprint server for health sciences · 2024Article
- Visual surround suppression at the neural and perceptual levels.Cognitive neurodynamics · 2024Review
- Stronger tilt aftereffects in individuals diagnosed with schizophrenia spectrum disorders but not bipolar disorder.Schizophrenia research · 2024Article
- Event-related potential (ERP) markers of 22q11.2 deletion syndrome and associated psychosis.Journal of neurodevelopmental disorders · 2023Review
- The psychosis human connectome project: Design and rationale for studies of visual neurophysiology.NeuroImage · 2023Article
- Impact of reduced-dimensionality independent components analysis on event-related potential measurements.Psychophysiology · 2023Article
- Weakened untuned gain control is associated with schizophrenia while atypical orientation-tuned suppression depends on visual acuity.Journal of vision · 2023Article
- Early visual processing and adaptation as markers of disease, not vulnerability: EEG evidence from 22q11.2 deletion syndrome, a population at high risk for schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Neural Indicator of Altered Mismatch Detection Predicts Atypical Cognitive-Perceptual Experiences in Psychotic Psychopathology.Schizophrenia bulletin · 2022Article
- Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience.Clinical psychology review · 2021Review
- Neural mechanisms underlying visual and auditory processing impairments in schizophrenia: insight into the etiology and implications for tailoring preventive and therapeutic interventions.American journal of translational research · 2020Review
- Neural anomalies during vigilance in schizophrenia: Diagnostic specificity and genetic associations.NeuroImage. Clinical · 2020Article
- Deficits in Auditory and Visual Sensory Discrimination Reflect a Genetic Liability for Psychosis and Predict Disruptions in Global Cognitive Functioning.Frontiers in psychiatry · 2020Article
- Perceptual Mechanisms of Visual Hallucinations and Illusions in Psychosis.Journal of psychiatry and brain science · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAccurate perception of visual contours is essential for seeing and differentiating objects in the environment. Both the ability to detect visual contours and the influence of perceptual context created by surrounding stimuli are diminished in people with schizophrenia (SCZ). The central aim of the present study was to better understand the biological underpinnings of impaired contour integration and weakened effects of perceptual context. Additionally, we sought to determine whether visual perceptual abnormalities reflect genetic factors in SCZ and are present in other severe mental disorders.
methodsWe examined behavioral data and event-related potentials (ERPs) collected during the perception of simple linear contours embedded in similar background stimuli in 27 patients with SCZ, 23 patients with bipolar disorder (BP), 23 first-degree relatives of SCZ, and 37 controls.
resultsSCZ exhibited impaired visual contour detection while BP exhibited intermediate performance. The orientation of neighboring stimuli (i.e. flankers) relative to the contour modulated perception across all groups, but SCZ exhibited weakened suppression by the perceptual context created by flankers. Late visual (occipital P2) and cognitive (centroparietal P3) neural responses showed group differences and flanker orientation effects, unlike earlier ERPs (occipital P1 and N1). Moreover, behavioral effects of flanker context on contour perception were correlated with modulation in P2 & P3 amplitudes.
conclusionIn addition to replicating and extending findings of abnormal contour integration and visual context modulation in SCZ, we provide novel evidence that the abnormal use of perceptual context is associated with higher-order sensory and cognitive processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.