Evidence map›Paper›PMID 31858761›Full record

ArticleAnnals of laboratory medicine2020

Development and Validation of a Novel Warfarin Dosing Algorithm for Korean Patients With

Eun Hye Cho, Kyunghoon Lee, Mina Yang, Rihwa Choi, Sun Young Baek, Insuk Sohn, June Soo Kim, Young Keun On, Oh Young Bang, Hyun Jung Cho and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of laboratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Balancing Beats and Bleeding: The Evolving Landscape of Atrial Fibrillation and Anticoagulation in the Past Two Decades.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eun Hye Cho *Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-9328-9389
Kyunghoon Lee *Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5014-3179
Mina YangDepartment of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.ORCID https://orcid.org/0000-0001-7431-6380
Rihwa ChoiDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8266-2248
Sun Young BaekStatistics and Data Center, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-6519-7770
Insuk SohnStatistics and Data Center, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-2126-9378
June Soo KimDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7569-6450
Young Keun OnDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1025-7283
Oh Young BangDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-7962-8751
Hyun Jung ChoDepartment of Laboratory Medicine, Konyang University Hospital, Konyang University School of Medicine, Daejeon, Korea. hjchomd@kyuh.ac.kr.ORCID https://orcid.org/0000-0003-1286-8395
Soo Youn LeeDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7595-4042

Funding

Korea Health Industry Development Institute HI13C2098
6 · The paper itself

Abstract

backgroundDifferences in the performance of suggested warfarin dosing algorithms among different ethnicities and genotypes have been reported; this necessitates the development of an algorithm with enhanced performance for specific population groups. Previous warfarin dosing algorithms underestimated warfarin doses in

methodsA total of 109 patients carrying

resultsThe developed algorithm is as follows: maintenance dose (mg/week)=exp [3.223-0.009×(age)+0.577×(body surface area [BSA])+0.178×(sex)-0.481×(

conclusionsThis is the first study to develop and validate a warfarin dosing algorithm based on data from

Indexed as

AlgorithmsAdultAgedAged, 80 and overAnticoagulantsAsian PeopleAtrial FibrillationCytochrome P-450 CYP2C9Dose-Response Relationship, DrugFemaleGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRegression AnalysisAnticoagulantsCytochrome P-450 CYP2C9Vitamin K Epoxide ReductasesWarfarinDosing algorithmGenotypeKoreaPerformanceVKORC1Warfarin

Identifiers

PMID31858761
PMCPMC6933054

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.