ArticleJournal of Korean medical science2019
Amplification of Stem Genes: New Potential Metastatic Makers in Patients with an Early Form of Breast Cancer.
Article in Journal of Korean medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Ectopic Male Breast Cancer in Suprapubic Area That Relapsed with Hematogenous Metastasis.Journal of breast cancer · 2021Article
- Article
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6 authors at 2 institutions in 1 country.
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Abstract
backgroundAccording to our previous studies, the presence of amplifications of stem genes can lead to their ectopic expression and this is associated with an increased activity of tumor stem cells in these patients. This leads to a high aggressiveness of the tumor and the development of metastatic disease. The aim was to evaluate the prognostic significance of the presence of amplifications of stem genes and their expression in patients with early breast cancer (BC).
methodsThe study included 28 patients with T₁NxM₀ BC. We used surgical specimens, including formalin-fixed paraffin-embedded archive materials, for 8 patients. A microarray analysis was performed on high-density DNA chips from CytoScanHDArray to assess the status of copy number aberration (CNA) of stem genes locus. Gene expression was assessed using RT-qPCR.
resultsCNA analysis of the studied tumors of patients without chemotherapy showed that 17/18 patients without metastases did not have two or more amplifications of chromosomal regions. Ten patients had visceral metastases. In 9/10 of these patients in the primary tumor there were two or more amplifications of the stem genes locus. Two or more amplifications of stem genes locus were found in 12 patients with stage I. Hematogenous metastases did not develop in all patients. Comparison of metastasis-free survival rates in groups of patients with 1 or without amplifications and with two or more amplifications showed statistically significant differences (
conclusionOur studies have shown that the presence of clones with two or more amplifications of stem gene in patients with BC T₁NxM₀ has a significant prognostic value and determines an unfavorable prognosis for distant metastasis.
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