ArticleBrain and behavior2020
Diffusion tensor imaging tractography reveals altered fornix in all diagnostic subtypes of multiple sclerosis.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.Neuropsychology · 2026Article
- Review
- Young versus older subject diffusion magnetic resonance imaging data for virtual white matter lesion tractography.Human brain mapping · 2023Article
- Comparison of recent updates in genetics, immunology, biomarkers, and neuroimaging of primary-progressive and relapsing-remitting multiple sclerosis and the role of ocrelizumab in the management of their refractory cases.Health science reports · 2023Article
- White matter tracts contribute selectively to cognitive functioning in patients with glioma.Frontiers in oncology · 2023Article
- Diffusion tensor tractography of the fornix in cerebral amyloid angiopathy, mild cognitive impairment and Alzheimer's disease.NeuroImage. Clinical · 2022Article
- Contribution of Gray Matter Atrophy and White Matter Damage to Cognitive Impairment in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Diffusion properties of the fornix assessed by deterministic tractography shows age, sex, volume, cognitive, hemispheric, and twin relationships in young adults from the Human Connectome Project.Brain structure & function · 2021Article
- Tract-specific MRI measures explain learning and recall differences in multiple sclerosis.Brain communications · 2021Article
- Modern Technology in Multi-Shell Diffusion MRI Reveals Diffuse White Matter Changes in Young Adults With Relapsing-Remitting Multiple Sclerosis.Frontiers in neuroscience · 2021Article
- Sodium Intensity Changes Differ Between Relaxation- and Density-Weighted MRI in Multiple Sclerosis.Frontiers in neurology · 2021Article
- Diffusion tensor imaging tractography reveals altered fornix in all diagnostic subtypes of multiple sclerosis.Brain and behavior · 2020Article
- Disproportional smaller fornix with altered microstructure in pediatric multiple sclerosis shown by high-resolution fluid-suppressed diffusion tractography.Multiple sclerosis journal - experimental, translational and clinicalArticle
- High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionDiffusion tensor imaging (DTI) has shown abnormalities of the fornix and other limbic white matter tracts in multiple sclerosis (MS), mainly focusing on relapsing-remitting MS.
methodsThe goal here was to evaluate the fornix, cingulum, and uncinate fasciculus with DTI tractography at 1.7 mm isotropic resolution in three MS subgroups (11 relapsing-remitting (RRMS), nine secondary progressive (SPMS), eight primary progressive (PPMS)) versus 11 controls, and assess correlations with cognitive and clinical scores.
resultsThe MS group overall showed extensive diffusion abnormalities of the fornix with less volume, lower fractional anisotropy (FA), and higher mean and radial diffusivities, which were similarly affected in all three MS subgroups. The uncinate fasciculus had lower FA only in the secondary progressive subgroup, and the cingulum had no DTI differences in any MS subgroup. The FA and/or volumes of these tracts correlated negatively with larger total lesion volume. The only DTI-cognitive correlation was lower right cingulum FA and greater depression over the entire MS cohort.
conclusionsDiffusion tractography identified abnormalities in the fornix that appears to be affected early and consistently across all three primary MS phenotypes of RRMS, SPMS, and PPMS regardless of Expanded Disability Status Scale, time since diagnosis, or cognitive scores.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.