Evidence map›Paper›PMID 31858394›Full record

Trial reportObesity surgery2020

Randomized, Double-Blind Study of the Effect of Intraoperative Intravenous Lidocaine on the Opioid Consumption and Criteria for Hospital Discharge After Bariatric Surgery.

Rioko K Sakata, Roclides C de Lima, Jose A Valadão, Plinio C Leal, Ed Cr Moura, Vitor P Cruz, Caio Mb de Oliveira

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04524130 (The Effect of Intraoperative Lidocaine Infusion and Intraoperative Lidocaine Combined With Ketamine Infusion on Opioid Consumption After Laparoscopic Bariatric Surgery), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04524130 phase4completednot on this mapstarted 2021, after this paper: background citation

The Effect of Intraoperative Lidocaine Infusion and Intraoperative Lidocaine Combined With Ketamine Infusion on Opioid Consumption After Laparoscopic Bariatric Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorMahidol UniversityRan2021 to 2025Enrolled87ConditionsLaparoscopic Bariatric SurgeryArmsLidocaine Hydrochloride, Ketamine, Placebo
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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  17. Intravenous Infusion of Lidocaine Can Accelerate Postoperative Early Recovery in Patients Undergoing Surgery for Obstructive Sleep Apnea.Medical science monitor : international medical journal of experimental and clinical research · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rioko K SakataUniversidade Federal de São Paulo, Rua Botucatu, São Paulo, 593, Brazil. rsakata@unifesp.br.ORCID 0000-0001-6159-1746
Roclides C de LimaSão Domingos Hospital, São Luis, Brazil.
Jose A ValadãoSão Domingos Hospital, São Luis, Brazil.
Plinio C LealUniversidade Federal do Maranhão, São Luis, Brazil.
Ed Cr MouraUniversidade Federal do Maranhão, São Luis, Brazil.
Vitor P CruzUniversidade Federal do Maranhão, São Luis, Brazil.
Caio Mb de OliveiraUniversidade Federal do Maranhão, São Luis, Brazil.
Universidade Federal do Maranhão · BRHospital São Domingos · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSurgical trauma, pain and opioids can cause nausea, vomiting, ileus and increased length of hospital stay. The primary objective of the study was to evaluate the time to recovery of gastrointestinal function and the time to meet hospital discharge criteria after laparoscopic bariatric surgery with intraoperative intravenous lidocaine administration. Secondary objectives were to evaluate morphine consumption during the first 24 h and the side effects of opioids.

methodsFifty-eight patients aged 18 to 60 years who underwent bariatric surgery were allocated into two groups. Group 1 patients received intravenous lidocaine (1.5 mg/kg) 5 min before induction of anaesthesia, followed by infusion (2 mg/kg/h) until the end of surgery. Group 2 patients were given 0.9% saline solution (placebo) and infusion of 0.9% saline solution during surgery, in same volume as group 1. Anaesthesia was performed with fentanyl (5 μg/kg), propofol (2 mg/kg), rocuronium (0.6 mg/kg) and sevoflurane. Postoperative patient-controlled analgesia was with morphine. There were two groups that were evaluated: time to recovery of gastrointestinal function and time to meet discharge criteria.

resultsThere was no significant difference between groups regarding the time to first flatus, time to meet discharge criteria and occurrence of side effects. Consumption of intraoperative sevoflurane and morphine over 24 h was significantly lower in the lidocaine group. Side effects observed were nausea and vomiting, with no difference between groups.

conclusionsPerioperative intravenous lidocaine is feasible and easily accessible when administered at appropriate doses. Lidocaine reduces morphine consumption.

Indexed as

Bariatric SurgeryObesity, MorbidAdolescentAdultAnalgesics, OpioidAnesthetics, LocalDouble-Blind MethodHospitalsHumansInfusions, IntravenousLidocaineMiddle AgedPatient DischargePostoperative PainProspective StudiesYoung AdultAnalgesics, OpioidAnesthetics, LocalLidocaineAnalgesiaBariatric surgeryDischargeLidocaine

Identifiers

PMID31858394
OpenAlexW2994726020

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.