Evidence map›Paper›PMID 31858293›Full record

ArticleEJNMMI research2019

Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand

Marius de Groot, Neel Patel, Roido Manavaki, Robert L Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J Graves, Yakshitha Karkera and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02350426 (An Adaptive Design Open Label Pilot Study in Rheumatoid Arthritis Patients to Assess Inflammation Using Molecular Imaging Techniques), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02350426 phase1terminatednot on this map

An Adaptive Design Open Label Pilot Study in Rheumatoid Arthritis Patients to Assess Inflammation Using Molecular Imaging Techniques

TypeinterventionalSponsorGlaxoSmithKlineRan2015 to 2016Enrolled10ConditionsArthritis, RheumatoidArmsGadobutrol, 18F-FDG, 18F-GE-180
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Advances in molecular imaging for osteoarthritis.Connective tissue research · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Have (R)-[European journal of nuclear medicine and molecular imaging · 2021
    Article
  8. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
  9. 18 F-FDG-PET/MRI in patients with Graves' orbitopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  10. Glia and Orofacial Pain: Progress and Future Directions.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Anatomy ofEuropean journal of nuclear medicine and molecular imaging · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Marius de GrootClinical Pharmacology and Experimental Medicine, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, UK.
Neel PatelClinical Pharmacology and Experimental Medicine, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, UK.
Roido ManavakiDepartment of Radiology, University of Cambridge, Cambridge, UK.
Robert L JaniczekClinical Pharmacology and Experimental Medicine, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, UK.
Mats BergstromClinical Pharmacology and Experimental Medicine, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, UK.
Andrew ÖstörMonash University, Cabrini Medical Centre, Melbourne, Australia.
Danielle GerlagRxCelerate, Cambridge, UK.
Alexandra RobertsClinical Pharmacology and Experimental Medicine, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, UK.
Martin J GravesDepartment of Radiology, University of Cambridge, Cambridge, UK.
Yakshitha KarkeraBiostatistics, GlaxoSmithKline R&D, Bangalore, India.
Disala FernandoClinical Unit Cambridge (CUC), GlaxoSmithKline R&D, Addenbrooke's Hospital, Cambridge, UK.
Prafull MistryBiostatistics, GlaxoSmithKline R&D, Bangalore, India.
Adam WalkerClinical Unit Cambridge (CUC), GlaxoSmithKline R&D, Addenbrooke's Hospital, Cambridge, UK.
Nicolas WisniackiClinical Pharmacology and Experimental Medicine, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, UK.
Tim D FryerWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Pilar Jimenez-RoyoClinical Pharmacology and Experimental Medicine, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, UK. Pilar.x.Jimenex-Royo@gsk.com.ORCID http://orcid.org/0000-0003-1959-6791
GlaxoSmithKline (United Kingdom) · GBUniversity of Cambridge · GBGlaxoSmithKline (India) · INHexcel (United Kingdom) · GBMonash Medical Centre · AU

Funding

GlaxoSmithKline NANational Institute for Health Research, Cambridge Biomedical Research Centre N/A
6 · The paper itself

Abstract

purposeWhile the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be valuable. Various imaging probes have shown value including dynamic contrast-enhanced (DCE) MRI and PET/CT using

methodsEight RA patients with moderate-to-high, stable disease activity and active disease in at least one wrist were included in this study (NCT02350426). Participants underwent PET/CT examinations with

resultsPET/CT imaging with

conclusionsThe correlations between DCE-MRI parameters and

Indexed as

FDGMRIPETRheumatoid arthritisTSPO

Identifiers

PMID31858293
PMCPMC6923307
OpenAlexW2995491971

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.