Evidence map›Paper›PMID 31858289›Full record

ArticleEJNMMI physics2019

Spill-in counts in the quantification of

Francisco Javier López-González, Alexis Moscoso, Nikos Efthimiou, Anxo Fernández-Ferreiro, Manuel Piñeiro-Fiel, Stephen J Archibald, Pablo Aguiar, Jesús Silva-Rodríguez, Alzheimer’s Disease Neuroimaging Initiative

Open access · goldAbstract read
In one paragraph

Article in EJNMMI physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. AI-enhanced Centiloid quantification of amyloid PET images.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Review
  5. Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?International journal of molecular sciences · 2024
    Review
  6. Article
  7. European journal of nuclear medicine and molecular imaging · 2022
    Article
  8. Reduced [European journal of nuclear medicine and molecular imaging · 2021
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Francisco Javier López-GonzálezMolecular Imaging and Medical Physics Group, Radiology Department, Faculty of Medicine, Universidade de Santiago de Compostela, Galicia, Spain.
Alexis MoscosoNuclear Medicine Department and Molecular Imaging Research Group, University Hospital (SERGAS) and Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.
Nikos EfthimiouPET Research Centre, Faculty of Health Sciences, University of Hull, Hull, UK.
Anxo Fernández-FerreiroPharmacy Department and Pharmacology Group, University Hospital (SERGAS) and Health Research Institute Santiago Compostela (IDIS), Santiago de Compostela, Galicia, Spain.
Manuel Piñeiro-FielMolecular Imaging and Medical Physics Group, Radiology Department, Faculty of Medicine, Universidade de Santiago de Compostela, Galicia, Spain.
Stephen J ArchibaldPET Research Centre, Faculty of Health Sciences, University of Hull, Hull, UK.
Pablo AguiarMolecular Imaging and Medical Physics Group, Radiology Department, Faculty of Medicine, Universidade de Santiago de Compostela, Galicia, Spain. pablo.aguiar.fernandez@sergas.es.ORCID http://orcid.org/0000-0002-7322-2195
Jesús Silva-RodríguezNuclear Medicine Department and Molecular Imaging Research Group, University Hospital (SERGAS) and Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Galicia, Spain.
Alzheimer’s Disease Neuroimaging Initiative
University of Hull · GBUniversidade de Santiago de Compostela · ESInstituto de Investigación Sanitaria de Santiago · ESServicio Gallego de Salud · ES

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
ISCIII pi16/01416NIA NIH HHS U01 AG024904Ramón y Cajal ryc-2015/17430
6 · The paper itself

Abstract

backgroundWe aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM in the reference region as a compensation. In addition, different partial volume correction (PVC) methods are applied and evaluated.

methodsWe evaluated magnetic resonance imaging and

resultsWM-SUVR

conclusionsThere is a high correlation between WM uptake and the measured SUVR due to spill-in effect, and that this effect is reduced when including WM in the reference region. We also evaluated the performance of PVC, and we proposed an analytical correction that can be applied to preprocessed data.

Indexed as

AmyloidPETPVEQuantificationSUV

Identifiers

PMID31858289
PMCPMC6923310
OpenAlexW2995602746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.