Evidence map›Paper›PMID 31858270›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2019

Citrate NMR peak irreproducibility in blood samples after reacquisition of spectra.

Munsoor A Hanifa, Raluca G Maltesen, Bodil S Rasmussen, Katrine B Buggeskov, Hanne B Ravn, Martin Skott, Søren Nielsen, Jørgen Frøkiær, Troels Ring, Reinhard Wimmer

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In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Munsoor A HanifaDepartment of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220, Aalborg, Denmark.ORCID 0000-0003-0040-7823
Raluca G MaltesenDepartment of Anesthesia and Intensive Care Medicine, Aalborg University Hospital, 9000, Aalborg, Denmark.ORCID 0000-0003-2332-2312
Bodil S RasmussenDepartment of Anesthesia and Intensive Care Medicine, Aalborg University Hospital, 9000, Aalborg, Denmark.ORCID 0000-0003-2190-145X
Katrine B BuggeskovDepartment of Cardiothoracic Anesthesiology, Rigshospitalet, Copenhagen University Hospital, 2100, Copenhagen, Denmark.ORCID 0000-0003-3455-1655
Hanne B RavnDepartment of Cardiothoracic Anesthesiology, Rigshospitalet, Copenhagen University Hospital, 2100, Copenhagen, Denmark.ORCID 0000-0003-4702-5195
Martin SkottDepartment of Urology, Aarhus University Hospital, 8250, Aarhus N, Denmark.ORCID 0000-0003-2048-4623
Søren NielsenMeta-IQ, Fredensgade 9, 8000, Aarhus C, Denmark.ORCID 0000-0001-7127-0356
Jørgen FrøkiærDepartment of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark.ORCID 0000-0002-6206-8065
Troels RingDepartment of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.ORCID 0000-0002-0193-6316
Reinhard WimmerDepartment of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220, Aalborg, Denmark. rw@bio.aau.dk.ORCID 0000-0001-6942-5056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn our metabolomics studies we have noticed that repeated NMR acquisition on the same sample can result in altered metabolite signal intensities.

aimsTo investigate the reproducibility of repeated NMR acquisition on selected metabolites in serum and plasma from two large human metabolomics studies.

methodsTwo peak regions for each metabolite were integrated and changes occurring after reacquisition were correlated.

resultsIntegral changes were generally small, but serum citrate signals decreased significantly in some samples.

conclusionsSeveral metabolite integrals were not reproducible in some of the repeated spectra. Following established protocols, randomising analysis order and biomarker validation are important.

Indexed as

Magnetic Resonance SpectroscopyBiomarkersCitric AcidHumansMetabolomicsPlasmaReproducibility of ResultsSerumBiomarkersCitric AcidMetabolomicsNMRPlasmaReproducibilitySerum

Identifiers

PMID31858270

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.