Evidence map›Paper›PMID 31858249›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

Hospital Anxiety and Depression Scale (HADS) accuracy in cancer patients.

Maria Antonietta Annunziata, Barbara Muzzatti, Ettore Bidoli, Cristiana Flaiban, Francesca Bomben, Marika Piccinin, Katiuscia Maria Gipponi, Giulia Mariutti, Sara Busato, Sara Mella

3 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 211 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 12 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05931068 recruitingnot on this mapstarted 2023, after this paper: background citation

Pre- and Postoperative Energy Expenditure in Major Liver Resection: What do we Ask From a Patient?

TypeobservationalSponsorAcademisch Ziekenhuis MaastrichtRan2023 to 2025Enrolled20ConditionsCancer, Liver Diseases, Liver NeoplasmsArmsPre- and postoperative assessment
NCT07032584 narecruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Multimodal Telerehabilitation on Reducing Disparities in Rural Survivors of Metastatic Prostate Cancer

TypeinterventionalSponsorUniversity of UtahRan2025 to 2029Enrolled74ConditionsProstate Cancer, Metastatic Prostate Cancer, Androgen Deprivation TherapyArmsTelerehabilitation Intervention
NCT07093177 narecruitingnot on this mapstarted 2026, after this paper: background citation

Multimodal Telerehabilitation of Rural Patients With Advanced Prostate Cancer

TypeinterventionalSponsorUniversity of UtahRan2026 to 2028Enrolled30ConditionsProstate CancerArmsTelerehabilitation Unit
3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 12 syntheses or guidelines pooled it, 305 citations in OpenAlex.

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  15. Patient-directed behavioral-physical interventions to alleviate acute hiccups associated with chemotherapy: a prospective randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  16. Characterization of multidimensional dyspnea in advanced lung cancer with moderate to severe dyspnea-related functional impairment: a latent profile analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Maria Antonietta AnnunziataUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy. annunziata@cro.it.ORCID http://orcid.org/0000-0001-9568-0368
Barbara MuzzattiUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Ettore BidoliUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.
Cristiana FlaibanUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Francesca BombenUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Marika PiccininUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Katiuscia Maria GipponiUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Giulia MariuttiUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Sara BusatoUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Sara MellaUnit of Oncological Psychology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Via F. Gallini, 2, 33081, Aviano, PN, Italy.
Centro di Riferimento Oncologico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe Hospital Anxiety and Depression Scale (HADS) is a self-report questionnaire designed to screen anxious and depressive states in patients in non-psychiatric settings. In spite of its large use, no agreement exists in literature on HADS accuracy in case finding. The present research addresses the issue of HADS accuracy in cancer patients, comparing its two subscales (HADS-A and HADS-D) against tools not in use in psychiatry, which are able to detect prolonged negative emotional states.

methods2121 consecutive adult cancer inpatients were administered the HADS together with the State Anxiety subscale of State-Trait Anxiety Inventory and the Center for Epidemiologic Studies Scale on Depression. Receiver operating characteristic (ROC) curves were computed to identify a cut-off for anxious and depressive states in cancer patients. All indicators were computed together with their corresponding 95% confidence interval (95% CI).

resultsData of 1628 and 1035 participants were used to assess the accuracy in case finding of HADS-A and HADS-D, respectively. According to the ROC analysis, the optimal cut-off was > 9 units for the HADS-A and > 7 units for the HADS-D. The area under the ROC curve was 0.90 for HADS-A (95% CI 0.88-0.91) and 0.84 for HADS-D (95% CI 0.81-0.86).

conclusionsThis study suggested that risk scores of anxious and depressive states above specific HADS cut-offs are useful in identifying anxious and depressive states in cancer patients, and they may thus be applicable in clinical practice.

Indexed as

AdolescentAdultAgedAged, 80 and overAnxietyDepressionFemaleHumansMaleMiddle AgedNeoplasmsPersonality InventoryPsychiatric Status Rating ScalesPsychometricsROC CurveSurveys and QuestionnairesAccuracyCancerHospital Anxiety and Depression ScaleOncologyPsychometricsReceiver operating characteristic curve

Identifiers

PMID31858249
OpenAlexW2995137269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.