Trial reportSurgical endoscopy2020
Cholelithiasis after bariatric surgery, incidence, and prophylaxis: randomized controlled trial.
Trial report in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04765618 (The Incidence of Gall Stones After Bariatric Surgery and Its Association With Weight Loss), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Incidence of Gall Stones After Bariatric Surgery and Its Association With Weight Loss
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Pooled it
- Role of Ursodeoxycholic Acid in the Prevention of Gallstones Formation in Bariatric Patients-a Systematic Review and Meta-Analysis of Randomised Trials.Obesity surgery · 2023Pooled it
- Incidence and risk factors for cholelithiasis after bariatric surgery: a systematic review and meta-analysis.Lipids in health and disease · 2023Pooled it
- Risk Factors for Symptomatic Gallstone Disease and Gallstone Formation After Bariatric Surgery.Obesity surgery · 2022Trial
- Comparative Analysis of the Incidence of Post-bariatric Cholelithiasis in Sleeve Gastrectomy and Roux-en-Y Gastric Bypass.Obesity surgery · 2025Article
- A Systematic Review and Meta-Analysis on the Efficacy and Safety of Concomitant Laparoscopic Cholecystectomy and Sleeve Gastrectomy in Patients with Morbid Obesity.Journal of clinical medicine · 2025Review
- Article
- Associations between sleeve gastrectomy, cholecystectomy, and gastroesophageal reflux disease in obese patients: an integrative review.Revista do Colegio Brasileiro de Cirurgioes · 2025Review
- Gallstones after bariatric surgery: mechanisms and prophylaxis.Frontiers in surgery · 2025Review
- Integrated Insights into Metabolic and Bariatric Surgery: Improving Life Quality and Reducing Mortality in Obesity.Medicina (Kaunas, Lithuania) · 2024Review
- Don't These Patients Deserve Better?Obesity surgery · 2024Article
- Review
- Gallstone formation and subsequent cholecystectomy after oncological gastric and esophageal resection.Langenbeck's archives of surgery · 2024Article
- Nutrition and Patient Follow-up in Bariatric Surgery.The Eurasian journal of medicine · 2023Article
- Review
- Prevalence of elevated alkaline phosphatase levels among post-bariatric surgery patients.Langenbeck's archives of surgery · 2023Article
- Ursodeoxycholic acid for prevention of gallstone disease after laparoscopic sleeve gastrectomy: an Atlantic Canada perspective.Surgical endoscopy · 2023Article
- Mid-term Results of an ERAS Program of Bariatric Surgery in a Tertiary Referral Center.World journal of surgery · 2023Article
- The Incidence of Cholelithiasis After Bariatric Surgery in Saudi Arabia and Its Associated Risk Factors.Cureus · 2023Article
- [Cholecystolithiasis and intestinal bypass procedures].Chirurgie (Heidelberg, Germany) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid weight loss is associated with a high incidence of cholelithiasis.
objectivesTo identify the incidence of gallstone formation after weight loss surgery and to detect the efficacy of 6 months regimen of prophylactic Ursodeoxycholic acid (UDCA).
methodsRCT included a total of 1530 morbid obese patients who were subjected to either laparoscopic one anastomosis gastric bypass (OAGB), sleeve gastrectomy (SG), or greater curve plication (GCP). Patients with previous or concomitant cholecystectomy and missed follow-up were excluded, leaving 1432 patients to analyze. They were randomly allocated into two groups receiving either UDCA or placebo with a minimum follow-up of one year for assessment of cholelithiasis and weight loss.
resultsThe overall incidence of cholelithiasis after surgery was 9.7%. There was a significant decrease in the incidence of gallstone formation from 22% in placebo to 6.5% in treated group with UDCA. The mean percentage of excess weight loss (%EWL) was significantly higher in those who develop gallstones than others. Of those developing gallstones, there was 64.7 % with SG versus 28.1% and 7.2% in OAGB and GCP, respectively, which is statistically significant. NNT to prevent cholelithiasis is six, AR% is 70.4%, and RR is 3.4%.
conclusionsCholelithiasis after SG and OAGB was higher than GCP. %EWL was rapid and higher in OAGB and SG contributing to the higher rate of symptomatic cholelithiasis and could be predictive for post-bariatric cholelithiasis. A 6-month use of UDCA is an effective prophylaxis decreasing gallstone formation after bariatric surgery at short-term follow-up.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.