ArticleJournal of gastroenterology2020
Comparison of prognosis between observation and surgical resection groups with small sporadic non-functional pancreatic neuroendocrine neoplasms without distant metastasis.
Article in Journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Clinical Utility of EUS-FNA/FNB for Diagnosis and Grade Assessment in Pancreatic Neuroendocrine Tumors < 20 mm: A Systematic Review and Meta-Analysis.Journal of hepato-biliary-pancreatic sciences · 2026Pooled it
- Surgical Versus Nonsurgical Management of Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis.Annals of surgical oncology · 2025Pooled it
- Contrast-enhanced endoscopic ultrasonography differentiated pancreatic schwannoma from concurrent neuroendocrine tumor.Clinical journal of gastroenterology · 2026Article
- Centralized Surgical Care Improves Survival in Non-Functional Well-Differentiated Pancreatic Neuroendocrine Tumors.Cancers · 2025Article
- Characteristics and outcomes of observed versus resected pancreatic neuroendocrine tumors.Proceedings (Baylor University. Medical Center) · 2025Article
- Small Insulinoma Followed-up as an Indolent Pancreatic Tumor.Internal medicine (Tokyo, Japan) · 2024Article
- Efficacy of endoscopic ultrasound-guided tissue acquisition for solid pancreatic lesions 20 mm or less in diameter suspected as neuroendocrine tumors or requiring differentiation.Journal of gastroenterology · 2023Article
- Surgical Management of Pancreatic Neuroendocrine Tumors.Cancers · 2023Review
- Characteristics of small pancreatic neuroendocrine tumors and risk factors for invasion and metastasis.Frontiers in endocrinology · 2023Article
- Management of Small Nonfunctioning Pancreatic Neuroendocrine Neoplasms: Current Opinion and Controversies.Journal of clinical medicine · 2022Review
- Value of lymphadenectomy in patients with surgically resected pancreatic neuroendocrine tumors.BMC surgery · 2022Article
- A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms.Diagnostics (Basel, Switzerland) · 2022Article
- Prognostic Factors of Small Non-Functional Pancreatic Neuroendocrine Tumors and the Risk of Lymph Node Metastasis: A Population-Level Study.Frontiers in endocrinology · 2022Article
- Role of Endoscopic Ultrasound in the Diagnosis of Pancreatic Neuroendocrine Neoplasms.Diagnostics (Basel, Switzerland) · 2021Review
- The Landmark Series: Pancreatic Neuroendocrine Tumors.Annals of surgical oncology · 2021Article
- Biliary Neuroendocrine Neoplasms: Analysis of Prognostic Factors and Development and Validation of a Nomogram.Frontiers in oncology · 2021Article
- Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors.Gastroenterology research and practice · 2021Article
- Risk of malignancy and prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors.Gland surgery · 2021Article
- Head and body/tail pancreatic neuroendocrine tumors have different biological characteristics and clinical outcomes.Journal of cancer research and clinical oncology · 2020Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe treatment of small (≤ 2 cm), sporadic localized non-functional pancreatic neuroendocrine neoplasms (PNENs) is often controversial. This study aimed to investigate the clinical outcomes with observation and surgical resection in small PNENs.
methodsSeventy-five patients with small localized sporadic non-functional PNENs ≤ 2 cm, who underwent observation or surgical resection, were retrospectively reviewed. Changes in tumor size during follow-up in the observation group were also investigated.
resultsThe median age of the cohort was 61 (range 35-81) years. The tumor grades were G1, G2, and unknown, in 61 (81.3%), 8 (10.7%), and 6 (8.0%) patients, respectively. The mean follow-up periods in the observation (n = 23) and surgical resection groups (n = 52) were 52.3 (range 6.8-133.3) months and 73.0 (range 9.1-179.9) months, respectively. The median overall survival was not reached. During follow-up, no patient died of PNENs, two died of other diseases, three had lymph node metastases, and one experienced recurrence after surgical resection. There was no significant difference in overall survival between the observation and surgical resection groups (hazard ratio: 0.031, P = 0.417). The mean change in tumor size in the observation group was + 0.30 mm (range - 1.6 to + 3.0 mm). No deaths, tumor progression, lymph node metastases, distant metastases, or recurrence were noted in patients with PNENs ≤ 1 cm (n = 36).
conclusionsThe prognosis of small localized PNENs is good. Observation may be an alternative to surgery in high-risk patients and those with small G1 tumors, particularly those measuring ≤ 1 cm.
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