Evidence map›Paper›PMID 31858203›Full record

ArticleEuropean radiology2020

Abbreviated MRI with optional multiphasic CT as an alternative to full-sequence MRI: LI-RADS validation in a HCC-screening cohort.

So Hyun Park, Bohyun Kim, So Yeon Kim, Young Sup Shim, Ju Hyun Kim, Jimi Huh, Hye Jin Kim, Kyung Won Kim, Seung Soo Lee

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04455932 (HCC Surveillance), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04455932 narecruitingnot on this mapstarted 2022, after this paper: background citation

HCC Surveillance: Comparison of Abbreviated Non-contrast MRI and Ultrasound Surveillance in Cirrhotic Patients With Suboptimal Ultrasound Visualisation

TypeinterventionalSponsorConcord Repatriation General HospitalRan2022 to 2027Enrolled476ConditionsHepatocellular Carcinoma, HCCArmsAbbreviated non-contrast MRI of the liver, Ultrasound surveillance, Multiphase contrast-enhanced liver MRI
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

So Hyun ParkDepartment of Radiology, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.
Bohyun KimDepartment of Radiology, Ajou University School of Medicine, Ajou University Hospital, 164 World-cup ro, Yeongtong-gu, Suwon, 16499, South Korea. kbh@ajou.ac.kr.ORCID http://orcid.org/0000-0003-1157-415X
So Yeon KimDivision of Abdominal Radiology, Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Young Sup ShimDepartment of Radiology, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.
Ju Hyun KimDepartment of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.
Jimi HuhDepartment of Radiology, Ajou University School of Medicine, Ajou University Hospital, 164 World-cup ro, Yeongtong-gu, Suwon, 16499, South Korea.
Hye Jin KimDepartment of Radiology, Ajou University School of Medicine, Ajou University Hospital, 164 World-cup ro, Yeongtong-gu, Suwon, 16499, South Korea.
Kyung Won KimDivision of Abdominal Radiology, Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Seung Soo LeeDivision of Abdominal Radiology, Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Ajou University Hospital · KRGachon University · KRUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the diagnostic performance of abbreviated MRI (AMRI) combined with multiphasic CT (mCT) with that of full-sequence gadoxetic acid-enhanced MRI (EOB-MRI) in a hepatocellular carcinoma (HCC)-screening cohort

methodsConsecutive patients at risk of HCC who underwent EOB-MRI and mCT within 3 months for evaluation of new 0.5-3-cm hepatic observations were retrospectively recruited from 3 centers. An AMRI protocol comprising hepatobiliary phase, T2- and diffusion-weighted imaging, and dual-echo sequence was reconstituted from EOB-MRI. Two radiologists independently reviewed each observation in AMRI plus mCT (set 1) and EOB-MRI (set 2) per LI-RADS v2018. Per-lesion sensitivity, accuracy, and positive predictive value (PPV) for HCC were calculated and compared between image sets.

resultsIn 267 patients, 306 histologically confirmed observations (280 HCCs, 20 combined hepatocellular-cholangiocarcinomas, 1 cholangiocarcinoma, and 5 benignities) were assessed. Set 1 yielded higher sensitivity (96.4% vs. 92.9%, p = 0.013) and comparable accuracy (91.2% vs. 87.6%) and PPV (94.1% vs. 93.5%) to set 2 using LI-RADS category (LR)-4/5 criteria. The sets showed comparable sensitivity (66.4% vs. 70.4%), accuracy (67.7% vs. 70.6%), and PPV (97.4% vs. 96.6%) using LR-5 criteria. A similar substantial number of non-HCC malignancies were categorized as LR-4 or LR-5, as was the number of HCCs categorized as LR-M in both sets.

conclusionsAMRI combined with mCT showed diagnostic performance similar or superior to that of EOB-MRI for HCC diagnosis using LI-RADS. Therefore, mCT holds potential as a sequential examination for HCC diagnosis in AMRI-detected hepatic observation in patients at risk of HCC. KEY POINTS: • AMRI plus multiphasic CT showed comparable accuracy (91.2%) and PPV (94.1%) to full-sequence gadoxetic acid-enhanced MRI using LR-4/5 criteria. • AMRI plus multiphasic CT was significantly more sensitive than full-sequence gadoxetic acid-enhanced MRI (96.4% vs. 92.9%) using LR-4/5 criteria. • Multiphasic CT is a potential sequential modality for HCC diagnosis after AMRI.

Indexed as

AlgorithmsCarcinoma, HepatocellularDiffusion Magnetic Resonance ImagingFemaleHumansLiverLiver NeoplasmsMaleMiddle AgedMultidetector Computed TomographyRetrospective StudiesHepatocellular carcinomaLiverMagnetic resonance imaging

Identifiers

PMID31858203
OpenAlexW2995589603

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.