ArticleDiabetologia2020
Age of obesity onset, cumulative obesity exposure over early adulthood and risk of type 2 diabetes.
Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Global, regional and time-trend prevalence of central obesity: a systematic review and meta-analysis of 13.2 million subjects.European journal of epidemiology · 2020Pooled it
- Type 2 diabetes prevention across the life course.Nature medicine · 2026Review
- Prepubertal Growth Trajectory and Pubertal Onset.JAMA network open · 2026Article
- Association Between Metabolic and Endocrine Parameters With Visceral Adiposity Index-Defined Adipose Tissue Dysfunction in Young Adult Males.Journal of obesity · 2026Article
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- Early-Onset of Obesity Model: Impact of Early-Onset Obesity on Comorbidity Risk and Life Expectancy.Obesity facts · 2026Article
- Waiting time for bariatric and metabolic surgery in the Brazilian public health system and comorbidities: what is the impact?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026Article
- Cumulative excess weight exposure over time and cardiovascular risk: A prospective cohort study.PloS one · 2026Article
- Trends in adolescent obesity in the Arab ethnic minority in Israel: an age-period-cohort analysis.BMC public health · 2025Article
- Association between neutrophil/ high-density lipoprotein cholesterol ratio and BMI in three Argentinean Indigenous communities.Biochemistry and biophysics reports · 2025Article
- Characterizing trajectories of diabetes-related health parameters before diabetes diagnosis in diabetes subtypes: analysis of a 20-year long prospective cohort study in Sweden.Cardiovascular diabetology · 2025Article
- Improving obesity management: Insights from the ACTION Switzerland survey of people with obesity, physicians and dietitians.Clinical obesity · 2025Observational
- Medication time of metformin and sulfonylureas and incidence of cardiovascular diseases and mortality in type 2 diabetes: a pooled cohort analysis.Scientific reports · 2025Article
- Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021.Lancet (London, England) · 2025Article
- Obesity pharmacotherapy in older adults: a narrative review of evidence.International journal of obesity (2005) · 2025Review
- Epidemiology of Overweight and Obesity in Early Childhood in China and Associated Factors.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss.Frontiers in immunology · 2025Article
- Article
- Association between obesity and systemic immune inflammation index, systemic inflammation response index among US adults: a population-based analysis.Lipids in health and disease · 2024Article
- Associations between Longitudinal Maternal and Cord Blood Vitamin D Status and Child Growth Trajectories Up to 4 Years of Age.Nutrients · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
aims/hypothesisObesity is a risk factor for type 2 diabetes, yet little is known about how timing and cumulative exposure of obesity are related to disease risk. The aim of this study was to examine the associations between BMI trajectories, age of onset of obesity and obese-years (a product of degree and duration of obesity) over early adulthood and subsequent risk of type 2 diabetes.
methodsWomen aged 18-23 years at baseline (n = 11,192) enrolled in the Australian Longitudinal Study on Women's Health (ALSWH) in 1996 were followed up about every 3 years via surveys for up to 19 years. Self-reported weights were collected up to seven times. Incident type 2 diabetes was self-reported. A growth mixture model was used to identify distinct BMI trajectories over the early adult life course. Cox proportional hazards regression models were used to examine the associations between trajectories and risk of diabetes.
resultsOne hundred and sixty-two (1.5%) women were newly diagnosed with type 2 diabetes during a mean of 16 years of follow-up. Six distinct BMI trajectories were identified, varying by different initial BMI and different slopes of increase. Initial BMI was positively associated with risk of diabetes. We also observed that age at onset of obesity was negatively associated with risk of diabetes (HR 0.87 [95% CI 0.79, 0.96] per 1 year increment), and number of obese-years was positively associated with diabetes (p for trend <0.0001). CONCLUSIONS/
interpretationOur data revealed the importance of timing of obesity, and cumulative exposure to obesity in the development of type 2 diabetes in young women, suggesting that preventing or delaying the onset of obesity and reducing cumulative exposure to obesity may substantially lower the risk of developing diabetes.
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