ArticleIndian journal of surgical oncology2019
This 'Rose' Has no Thorns-Diagnostic Utility of 'Rapid On-Site Evaluation' (ROSE) in Fine Needle Aspiration Cytology.
Article in Indian journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 30 citations in OpenAlex.
- Evaluation of Noninvasive Adjuncts for Early Detection of Oral Cancer in Oral Potentially Malignant Disorders and Development of Risk-Based Management Strategies: Protocol for a Prospective Longitudinal Study.JMIR research protocols · 2025Article
- Evaluation of Optimized Toluidine Blue Stain as an Alternative Stain for Rapid On-Site Evaluation (ROSE).Diagnostics (Basel, Switzerland) · 2025Article
- Rapid On-site Evaluation (ROSE) Cytology of Mucoepidermoid Carcinoma and its Diagnostic Pitfalls: a Case Report.Indian journal of surgical oncology · 2024Article
- Primary Thyroid Lymphoma Diagnosed on Rapid Onsite and Cytology: A Rare Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Rapid onsite evaluation in cytomorphology of Hydatidosis: A useful adjunct to diagnosis.IDCases · 2022Article
- ROSE in Rosai-Dorfman-Destombes (RDD) disease: a cytological diagnosis.European journal of medical research · 2021Article
- Comparison of the Detection Rates of Different Diagnostic Methods for Primary Peripheral Lung Cancer.Frontiers in oncology · 2021Article
- Phaeoacremonium species detected in fine needle aspiration: a rare case report.Diagnostic pathology · 2020Article
- Adenoid Cystic Carcinoma Breast: a Rare Entity.Indian journal of surgical oncology · 2020Article
- Fibroadenoma versus phyllodes tumor: a vexing problem revisited!BMC cancer · 2020Article
- Atypical Hansen's Disease Mimicking Xanthogranuloma: Role of Cytology.Journal of cutaneous and aesthetic surgeryArticle
- FNAC of Breast Lesions with Special Reference to IAC Standardized Reporting and Comparative Study of Cytohistological Grading of Breast Carcinoma.Journal of cytologyArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fine needle aspiration (FNA) cytology is a basic diagnostic technique used to investigate superficial and deep swellings. Rapid on-site evaluation (ROSE) using toluidine blue (TB) is easily available, cheap, cost-effective, can be used both for testing adequacy and giving provisional diagnosis. To evaluate the role of ROSE using toluidine blue staining in arriving at a diagnosis in comparison to routine stains. A total of 1500 cases of FNA of palpable swellings from sites like salivary gland, breast, thyroid, lymph node, and soft tissue lesions [non-image guided] during a 9-month period were studied. All the cases were evaluated by ROSE using toluidine blue stain and routine Giemsa/PAP staining. The results were compared in each case. Only 2% cases proved inadequate on TB, Giemsa and PAP combination, commonest site of inadequacy being lymph node. Adequate sample was obtained within two passes in 92.5% cases. The turn-around time (TAT) was 1 day in 96.4% of cases. The average time for making a provisional diagnosis on TB was 3 minutes. There was 99.2% concordance between TB and final cyto-diagnosis. Validity parameters: sensitivity 98%, specificity 100%, positive predictive value 100%, negative predictive value 99.8%, efficacy 99.2% and false negative 1.94%. ROSE using toluidine blue is a reliable means of demonstrating sample adequacy, for making a provisional diagnosis and guiding collection of diagnostic material for microbiology, immunocytochemistry (ICC), cell block and molecular testing etc. The technique is easy enough for general laboratories to incorporate into their routine practice. ROSE can be called as the "
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