ReviewThe Clinical biochemist. Reviews2019
Superwarfarin (Long-Acting Anticoagulant Rodenticides) Poisoning: from Pathophysiology to Laboratory-Guided Clinical Management.
Review in The Clinical biochemist. Reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Clinical analysis of 26 children with long-acting anticoagulant rodenticides (superwarfarin) poisoning.Research and practice in thrombosis and haemostasis · 2026Article
- Intraspinal hematoma caused by anticoagulant rodenticide poisoning: a rare case report.Frontiers in medicine · 2026Article
- Aortic dissection precipitated by superwarfarin (brodifacoum) poisoning: a case report and pathophysiological review.Frontiers in surgery · 2026Article
- A Case Report of Severe Bromadiolone Poisoning: Blood Toxicology Levels and Correlation to Clinical Toxicity.Cureus · 2025Article
- Rivaroxaban use during vitamin KResearch and practice in thrombosis and haemostasis · 2025Article
- Acute kidney injury induced by mixed poisoning with brodifacoum and bromadiolone: a case report.Frontiers in medicine · 2025Article
- Article
- Deploying Validated Mass Spectrometry for Frontline Detection and Treatment of Human Poisoning by Long-Acting Anticoagulant Rodenticides.Chemical research in toxicology · 2024Article
- Radiological findings in poisoning by synthetic cannabinoids adulterated with brodifacoum.European radiology · 2024Article
- Article
- Superwarfarin poisoning: challenges still remain.BMJ case reports · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superwarfarins are long-acting anticoagulant rodenticides developed from warfarin. The mechanism of action is by inhibition of vitamin K epoxide reductase, resulting in the inability of the body to recycle vitamin K. Deficiency of vitamin K thereafter leads to inability for the body to synthesise vitamin K-dependent coagulation factors, factor II, VII, IX, and X, leading to prolonged prothrombin time. Due to the bulky aromatic sidechains, superwarfarins have a much longer half-life when compared to warfarin, and exposure to superwarfarins results in a prolonged period of anticoagulation which can result in clinical bleeding. Diagnosis is straightforward in patients with known history of superwarfarin exposure but has proved difficult for patients who did not report superwarfarin intake. Superwarfarin poisoning should therefore be suspected in all patients with unexplained prolongation of prothrombin time, and can be confirmed by their detection in serum. Treatment for superwarfarin poisoning includes rapid correction of factor deficiencies with either 4-factor prothrombin complex concentrate or fresh frozen plasma in patients with active bleeding, and high dose vitamin K therapy given multiple times per day for a prolonged period of weeks to months.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.