Evidence map›Paper›PMID 31857736›Full record

ArticleComputer methods in applied mechanics and engineering2019

Coupling brain-tumor biophysical models and diffeomorphic image registration.

Klaudius Scheufele, Andreas Mang, Amir Gholami, Christos Davatzikos, George Biros, Miriam Mehl

Abstract read
In one paragraph

Article in Computer methods in applied mechanics and engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Estimating Glioblastoma Biophysical Growth Parameters Using Deep Learning Regression.Brainlesion : glioma, multiple sclerosis, stroke and traumatic brain injuries. BrainLes (Workshop) · 2021
    Article
  6. Article
  7. Multiatlas Calibration of Biophysical Brain Tumor Growth Models with Mass Effect.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2020
    Article
  8. Review
  9. Article
  10. IMAGE-DRIVEN BIOPHYSICAL TUMOR GROWTH MODEL CALIBRATION.SIAM journal on scientific computing : a publication of the Society for Industrial and Applied Mathematics · 2020
    Article
  11. CLAIRE: A DISTRIBUTED-MEMORY SOLVER FOR CONSTRAINED LARGE DEFORMATION DIFFEOMORPHIC IMAGE REGISTRATION.SIAM journal on scientific computing : a publication of the Society for Industrial and Applied Mathematics · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Klaudius ScheufeleUniversity of Stuttgart, IPVS, Universitätstraße 38, 70569 Stuttgart, Germany.
Andreas MangUniversity of Houston, Department of Mathematics, 3551 Cullen Blvd., Houston, TX 77204-3008, USA.
Amir GholamiUniversity of California Berkeley, EECS, Berkeley, CA 94720-1776, USA.
Christos DavatzikosDepartment of Radiology, University of Pennsylvania School of Medicine, 3700 Hamilton Walk, Philadelphia, PA 19104, USA.
George BirosUniversity of Texas, ICES, 201 East 24th St, Austin, TX 78712-1229, USA.
Miriam MehlUniversity of Stuttgart, IPVS, Universitätstraße 38, 70569 Stuttgart, Germany.

Funding

Statistical atlases of brain tumor MRI:do imaging phenotypes predict progression?R01NS042645 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2002 to 2024
$8.7M
NINDS NIH HHS R01 NS042645
6 · The paper itself

Abstract

We present SIBIA (Scalable Integrated Biophysics-based Image Analysis), a framework for joint image registration and biophysical inversion and we apply it to analyze MR images of glioblastomas (primary brain tumors). We have two applications in mind. The first one is normal-to-abnormal image registration in the presence of tumor-induced topology differences. The second one is biophysical inversion based on single-time patient data. The underlying optimization problem is highly non-linear and non-convex and has not been solved before with a gradient-based approach. Given the segmentation of a normal brain MRI and the segmentation of a cancer patient MRI, we determine tumor growth parameters and a registration map so that if we "grow a tumor" (using our tumor model) in the normal brain and then register it to the patient image, then the registration mismatch is as small as possible. This "

Indexed as

35K5749K2049M1565K1068W10Adjoint-based methodsAtlas registrationBiophysically constrained diffeomorphic image registrationParallel algorithmsTumor growth

Identifiers

PMID31857736
PMCPMC6922029

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.