Evidence map›Paper›PMID 31857689›Full record

SynthesisMolecular psychiatry2021

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.

Emily L Dennis, Seth G Disner, Negar Fani, Lauren E Salminen, Mark Logue, Emily K Clarke, Courtney C Haswell, Christopher L Averill, Lee A Baugh, Jessica Bomyea and 97 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 11 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 11 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

107 authors at 20 institutions in 8 countries.

Emily L DennisPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA. emily.dennis@hsc.utah.edu.ORCID http://orcid.org/0000-0001-7112-4009
Seth G DisnerMinneapolis VA Health Care System, Minneapolis, MN, USA.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7720-252X
Lauren E SalminenImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Mark LogueNational Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.
Emily K ClarkeBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3553-2990
Courtney C HaswellBrain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Christopher L AverillClinical Neuroscience Division, National Center for PTSD; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Lee A BaughDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Jessica BomyeaCenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA.
Steven E BruceDepartment of Psychological Sciences, Center for Trauma Recovery University of Missouri-St. Louis, St. Louis, MO, USA.
Jiook ChaDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Kyle ChoiHealth Services Research Center, University of California, San Diego, CA, USA.
Nicholas D DavenportMinneapolis VA Health Care System, Minneapolis, MN, USA.
Maria DensmoreDepartment of Psychiatry, Western University, London, ON, Canada.
Stefan du PlessisDepartment of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Gina L ForsterDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Jessie L FrijlingDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Atilla GonencCognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USA.
Staci GruberCognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, MA, USA.
Daniel W GrupeCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-4927-7572
Jeffrey P GuenetteDivision of Neuroradiology, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4684-5469
Jasmeet HayesDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
David HofmannInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Jonathan IpserSA Medical Research Council Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Tanja JovanovicDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Sinead KellyPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Mitzy KennisBrain Center Rudolf Magnus, Department of Psychiatry, UMCU, Utrecht, The Netherlands.
Philipp KinzelPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Saskia B J KochDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3628-6712
Inga KoertePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1281-9286
Sheri KoopowitzSA Medical Research Council Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Mayuresh KorgaonkarBrain Dynamics Centre, Westmead Institute of Medical Research, University of Sydney, Westmead, NSW, Australia.
John KrystalClinical Neuroscience Division, National Center for PTSD; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Lauren A M LeboisDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5816-9181
Gen LiLaboratory for Traumatic Stress Studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Vincent A MagnottaDepartments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Antje MantheyUniversity Medical Centre Charite, Berlin, Germany.
Geoff J MayVISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Deleene S MenefeeMenninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.
Laura NawijnDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Steven M NelsonVISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Richard W J NeufeldDepartment of Psychiatry, Western University, London, ON, Canada.
Jack B NitschkeDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Daniel O'DohertyUniversity of the Sunshine Coast, Birtinya, QLD, Australia.
Matthew PeverillDepartment of Psychology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8257-1004
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Annerine RoosSouth African Medical Research Council / Stellenbosch University Genomics of Brain Disorders Research Unit, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Margaret A SheridanDepartment of Psychology and Brain Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anika SierkUniversity Medical Centre Charite, Berlin, Germany.ORCID http://orcid.org/0000-0002-1396-8075
Alan SimmonsCenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA.
Raluca M SimonsCenter for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.
Jeffrey S SimonsSioux Falls VA Health Care System, Sioux Falls, SD, USA.
Jennifer StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-4674-0314
Benjamin Suarez-JimenezDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Danielle R SullivanNational Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0141-5887
Jean ThébergeDepartment of Psychiatry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0001-7578-4469
Jana K TranHouston Fire Department, Houston, TX, USA.
Leigh van den HeuvelDepartment of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.ORCID http://orcid.org/0000-0003-3884-4754
Steven J A van der WerffDepartment of Psychiatry, LUMC, Leiden, The Netherlands.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-0160-7248
Mirjam van ZuidenDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Carmen VelezDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Mieke VerfaellieDepartment of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Robert R J M VermeirenDepartment of Psychiatry, LUMC, Leiden, The Netherlands.
Benjamin S C WadeDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Tor WagerDartmouth College, Hanover, NH, USA.ORCID http://orcid.org/0000-0002-1936-5574
Henrik WalterUniversity Medical Centre Charite, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Sherry WinternitzDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Jonathan WolffDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
Gerald YorkJoint Trauma System, 3698 Chambers Pass, Joint Base San Antonio, Fort Sam Houston, TX, USA.
Ye ZhuLaboratory for Traumatic Stress Studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Xi ZhuDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Chadi G AbdallahClinical Neuroscience Division, National Center for PTSD; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5783-6181
Richard BryantSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9607-819X
Judith K DanielsDepartment of Clinical Psychology, University of Groningen, Groningen, The Netherlands.
Richard J DavidsonCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
Kelene A FerchoDivision of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
Carol FranzDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Elbert GeuzeBrain Center Rudolf Magnus, Department of Psychiatry, UMCU, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-3479-2379
Evan M GordonVISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Milissa L KaufmanDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
William S KremenCenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA.
Jim LagopoulosUniversity of the Sunshine Coast, Birtinya, QLD, Australia.
Ruth A LaniusDepartment of Psychiatry, Western University, London, ON, Canada.
Michael J LyonsDept. of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
Stephen R McCauleyDepartments of Neurology and Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Regina McGlincheyDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Katie A McLaughlinDepartment of Psychology, Harvard University, Cambridge, MA, USA.
William MilbergDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Yuval NeriaDepartment of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Miranda OlffDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Soraya SeedatSouth African Medical Research Council / Stellenbosch University Genomics of Brain Disorders Research Unit, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-5118-786X
Martha ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Scott R SponheimMinneapolis VA Health Care System, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-2782-0856
Dan J SteinSA Medical Research Council Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Murray B SteinDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9564-2871
Thomas StraubeInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
David F TateDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0213-1920
Nic J A van der WeeDepartment of Psychiatry, LUMC, Leiden, The Netherlands.
Dick J VeltmanDepartment of Psychiatry, Amsterdam University Medical Centers, Location VU University Medical Center, VU University, Amsterdam, The Netherlands.
Li WangLaboratory for Traumatic Stress Studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Elisabeth A WildeDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Peter KochunovMaryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Neda Jahanshad *Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Rajendra A Morey *Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Harvard University · USBrigham and Women's Hospital · USUniversity of California San Diego · USSouth African Medical Research Council · ZAAmsterdam UMC Location University of Amsterdam · NLBoston University · USColumbia University Irving Medical Center · USEmory University · USUniversity of South Dakota · USWestern University · CABaylor College of Medicine · USBaylor University · USCharité - Universitätsmedizin Berlin · DEDuke University · USImaging Center · USInstitute of Psychology, Chinese Academy of Sciences · CNLeiden University Medical Center · NLUniversity of Minnesota · USUniversity of Missouri–St. Louis · USUniversity of Wisconsin–Madison · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 1985 to 2015
$25.2M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
TRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6M
Striatal D2/D3 Dopamine receptor availability in first episode schizophreniaP50MH080173 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI GREGERSEN, PETER K. · 2008 to 2012
$10.4M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Neural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6M
BLRD VA I01 BX005918CSRD VA I01 CX000715CSRD VA I01 CX001542CSRD VA IK2 CX001680CSRD VA IK2 CX001772NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001863NCRR NIH HHS M01 RR000039NIAID NIH HHS R38 AI140299NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG058822NIA NIH HHS R01 AG059874NIA NIH HHS R56 AG058854NIA NIH HHS U54 AG062334NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NICHD NIH HHS K12 HD085850NICHD NIH HHS P30 HD003352NICHD NIH HHS R01 HD071982NIDA NIH HHS R01 DA035484NIH HHS S10 OD023696NIMH NIH HHS F32 MH109274NIMH NIH HHS K01 MH109836NIMH NIH HHS K01 MH115247NIMH NIH HHS K01 MH118428NIMH NIH HHS K01 MH118467NIMH NIH HHS K23 MH090366NIMH NIH HHS K23 MH101380NIMH NIH HHS K23 MH101498NIMH NIH HHS K24 MH110807NIMH NIH HHS P30 MH090590NIMH NIH HHS P50 MH080173NIMH NIH HHS R01 MH043454NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH076995NIMH NIH HHS R01 MH077851NIMH NIH HHS R01 MH077852NIMH NIH HHS R01 MH077862NIMH NIH HHS R01 MH078113NIMH NIH HHS R01 MH092440NIMH NIH HHS R01 MH102377NIMH NIH HHS R01 MH105355NIMH NIH HHS R01 MH108574NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117292NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH119222NIMH NIH HHS R01 MH119227NIMH NIH HHS R01 MH131532NIMH NIH HHS R03 MH110745NIMH NIH HHS R21 MH098212NIMH NIH HHS R21 MH112956NIMH NIH HHS R56 MH071537NIMH NIH HHS T32 MH016259NIMH NIH HHS T32 MH018931NIMH NIH HHS U01 MH109977NINDS NIH HHS K99 NS096116RRD VA I01 RX000622RRD VA IK1 RX002325RRD VA IK2 RX000709RRD VA IK2 RX002922
6 · The paper itself

Abstract

A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.

Indexed as

Stress Disorders, Post-TraumaticWhite MatterAdolescentAdultAgedAged, 80 and overAnisotropyBrainDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedYoung Adult

Identifiers

PMID31857689
PMCPMC7302988
OpenAlexW2995065313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.