Evidence map›Paper›PMID 31857684›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2020

Comprehensive profiling of disease-relevant copy number aberrations for advanced clinical diagnostics of pediatric acute lymphoblastic leukemia.

Richárd Kiss, Ambrus Gángó, Anne Benard-Slagter, Bálint Egyed, Irén Haltrich, Lajos Hegyi, Karel de Groot, Péter Attila Király, Szilvia Krizsán, Béla Kajtár and 9 more

Open access · bronzeAbstract read
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In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Richárd KissMTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Ambrus GángóMTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Anne Benard-SlagterMRC Holland, Amsterdam, The Netherlands.
Bálint Egyed2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Irén Haltrich2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Lajos HegyiMTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Karel de GrootMRC Holland, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4554-9796
Péter Attila KirályMTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Szilvia KrizsánMTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-1782-9275
Béla KajtárDepartment of Pathology, University of Pécs Clinical Centre, Pécs, Hungary.
Henriett PikóDepartment of Molecular Genetics and Diagnostics, National Center of Public Health, Budapest, Hungary.
László PajorDepartment of Pathology, University of Pécs Clinical Centre, Pécs, Hungary.
Ágnes VojcekDepartment of Paediatrics, University of Pécs Clinical Centre, Pécs, Hungary.
András MatolcsyMTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Gábor Kovács2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Károly SzuhaiDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-1228-4245
Suvi SavolaMRC Holland, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6221-8617
Csaba Bödör *MTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Donát Alpár *MTA-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. alpar.donat@med.semmelweis-univ.hu.ORCID http://orcid.org/0000-0002-2638-5418
Semmelweis University · HUMRC Holland (Netherlands) · NLUniversity of Pecs · HULeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lymphoblastic leukemia is the most common pediatric cancer characterized by a heterogeneous genomic landscape with copy number aberrations occurring at various stages of pathogenesis, disease progression, and treatment resistance. In this study, disease-relevant copy number aberrations were profiled in bone marrow samples of 91 children with B- or T-cell precursor acute lymphoblastic leukemia using digital multiplex ligation-dependent probe amplification (digitalMLPA

Indexed as

AdolescentChildChild, PreschoolDNA Copy Number VariationsFemaleGene Expression ProfilingHumansInfantMaleMultiplex Polymerase Chain ReactionPrecursor Cell Lymphoblastic Leukemia-Lymphoma

Identifiers

PMID31857684
OpenAlexW2996548408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.