ArticleNature communications2019
Enhancing plasticity in central networks improves motor and sensory recovery after nerve damage.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04534556 (Wireless Nerve Stimulation Device To Enhance Recovery After Stroke), which is not on this map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Wireless Nerve Stimulation Device To Enhance Recovery After Stroke
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Central Post-Stroke Pain: An Integrative Review of Somatotopic Damage, Clinical Symptoms, and Neurophysiological Measures.Frontiers in neurology · 2021Pooled it
- At-Home Delivery of Vagus Nerve Stimulation Paired With Task-Specific Training Improves Performance of High-Priority Activities in Persons With Chronic Spinal Cord Injury or Stroke.American journal of physical medicine & rehabilitation · 2026Trial
- Trial
- Transcutaneous Cervical Vagus Nerve Stimulation Improves Speech Comprehension in Noise: A Crossover, Placebo-Controlled Study.Neuromodulation : journal of the International Neuromodulation Society · 2025Trial
- Trial
- Rehabilitation strategies for abdominal wall reinnervation after intercostal nerve injury: A narrative review.The Journal of international medical research · 2026Review
- Right vagus nerve stimulation promotes motor cortical plasticity.Scientific reports · 2026Article
- Vagus Nerve Stimulation for Neuromodulation: Evolution from Bench to Bedside.Neurology international · 2026Article
- Functional connectivity during drawing after upper extremity peripheral nerve surgery: enhanced connectivity between motor and visuomotor-parietal regions.bioRxiv : the preprint server for biology · 2026Article
- Changes in Spinal Neural Circuit Plasticity in a Rat Sciatic Nerve Transection Model.Brain and behavior · 2026Article
- Transient synaptic refinement and glial adaptations after whisker denervation in adult mice.Frontiers in cellular neuroscience · 2026Article
- Transcutaneous auricular vagus nerve stimulation for disorders of consciousness: a narrative review of neurophysiological mechanisms, clinical evidence, and future directions.Frontiers in human neuroscience · 2026Review
- Multimodal MRI links gray matter volume loss and temporal lobe susceptibility to CSF immunological profiles in Guillain-Barré syndrome.Frontiers in immunology · 2026Article
- Transcutaneous auricular vagus nerve stimulation reduces error amplitude during force field learning in healthy adults.Scientific reports · 2025Article
- Enhancing peripheral nerve regeneration with rehabilitation and biomaterial-driven drug delivery strategies.Progress in biomedical engineering (Bristol, England) · 2025Review
- Transcutaneous auricular vagus nerve stimulation enhances structural and functional remodeling in sensorimotor networks following intracerebral hemorrhage in rats.Journal of neuroengineering and rehabilitation · 2025Article
- Enhancing Neuroplasticity via vagus nerve stimulation to improve urinary dysfunction after spinal cord injury: a perspective.Bioelectronic medicine · 2025Review
- Neuroplasticity and Nervous System Recovery: Cellular Mechanisms, Therapeutic Advances, and Future Prospects.Brain sciences · 2025Review
- Vagus Nerve Stimulation in Stroke Management: Brief Review of Evolution and Present Applications Paired with Rehabilitation.Brain sciences · 2025Review
- Transcutaneous cervical vagus nerve stimulation improves speech comprehension in noise: A crossover, placebo-controlled study.bioRxiv : the preprint server for biology · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Nerve damage can cause chronic, debilitating problems including loss of motor control and paresthesia, and generates maladaptive neuroplasticity as central networks attempt to compensate for the loss of peripheral connectivity. However, it remains unclear if this is a critical feature responsible for the expression of symptoms. Here, we use brief bursts of closed-loop vagus nerve stimulation (CL-VNS) delivered during rehabilitation to reverse the aberrant central plasticity resulting from forelimb nerve transection. CL-VNS therapy drives extensive synaptic reorganization in central networks paralleled by improved sensorimotor recovery without any observable changes in the nerve or muscle. Depleting cortical acetylcholine blocks the plasticity-enhancing effects of CL-VNS and consequently eliminates recovery, indicating a critical role for brain circuits in recovery. These findings demonstrate that manipulations to enhance central plasticity can improve sensorimotor recovery and define CL-VNS as a readily translatable therapy to restore function after nerve damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.