Evidence map›Paper›PMID 31857349›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2020

Genome-Wide Small Interfering RNA Screening Reveals a Role for Cullin3-Really Interesting New Gene Ligase Signaling in Heterologous Sensitization of Adenylyl Cyclase.

Zhong Ding, Karin F K Ejendal, Monica Soto-Velasquez, Michael P Hayes, Nicholas Santoro, Martha J Larsen, Val J Watts

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Neddylation steers the fate of cellular receptors.Experimental & molecular medicine · 2024
    Review
  2. KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhong DingDepartment of Medicinal Chemistry and Molecular Pharmacology (Z.D., K.F.K.E., M.S.-V., M.P.H., V.J.W.), Purdue Institute for Drug Discovery (V.J.W.), and Purdue Institute for Integrative Neuroscience (V.J.W.), Purdue University, West Lafayette, Indiana; and Center for Chemical Genomics, University of Michigan, Ann Arbor, Michigan (N.S., M.J.L.).
Karin F K EjendalDepartment of Medicinal Chemistry and Molecular Pharmacology (Z.D., K.F.K.E., M.S.-V., M.P.H., V.J.W.), Purdue Institute for Drug Discovery (V.J.W.), and Purdue Institute for Integrative Neuroscience (V.J.W.), Purdue University, West Lafayette, Indiana; and Center for Chemical Genomics, University of Michigan, Ann Arbor, Michigan (N.S., M.J.L.).
Monica Soto-VelasquezDepartment of Medicinal Chemistry and Molecular Pharmacology (Z.D., K.F.K.E., M.S.-V., M.P.H., V.J.W.), Purdue Institute for Drug Discovery (V.J.W.), and Purdue Institute for Integrative Neuroscience (V.J.W.), Purdue University, West Lafayette, Indiana; and Center for Chemical Genomics, University of Michigan, Ann Arbor, Michigan (N.S., M.J.L.).
Michael P HayesDepartment of Medicinal Chemistry and Molecular Pharmacology (Z.D., K.F.K.E., M.S.-V., M.P.H., V.J.W.), Purdue Institute for Drug Discovery (V.J.W.), and Purdue Institute for Integrative Neuroscience (V.J.W.), Purdue University, West Lafayette, Indiana; and Center for Chemical Genomics, University of Michigan, Ann Arbor, Michigan (N.S., M.J.L.).
Nicholas SantoroDepartment of Medicinal Chemistry and Molecular Pharmacology (Z.D., K.F.K.E., M.S.-V., M.P.H., V.J.W.), Purdue Institute for Drug Discovery (V.J.W.), and Purdue Institute for Integrative Neuroscience (V.J.W.), Purdue University, West Lafayette, Indiana; and Center for Chemical Genomics, University of Michigan, Ann Arbor, Michigan (N.S., M.J.L.).
Martha J LarsenDepartment of Medicinal Chemistry and Molecular Pharmacology (Z.D., K.F.K.E., M.S.-V., M.P.H., V.J.W.), Purdue Institute for Drug Discovery (V.J.W.), and Purdue Institute for Integrative Neuroscience (V.J.W.), Purdue University, West Lafayette, Indiana; and Center for Chemical Genomics, University of Michigan, Ann Arbor, Michigan (N.S., M.J.L.).
Val J WattsDepartment of Medicinal Chemistry and Molecular Pharmacology (Z.D., K.F.K.E., M.S.-V., M.P.H., V.J.W.), Purdue Institute for Drug Discovery (V.J.W.), and Purdue Institute for Integrative Neuroscience (V.J.W.), Purdue University, West Lafayette, Indiana; and Center for Chemical Genomics, University of Michigan, Ann Arbor, Michigan (N.S., M.J.L.) wattsv@purdue.edu.
Purdue University West Lafayette · USUniversity of Michigan–Ann Arbor · US

Funding

Understanding adaptive signaling of neuronal adenyly cyclases using siRNAR33MH101673 · NIMH · PURDUE UNIVERSITY · PI WATTS, VAL J · 2015 to 2016
$889k
Identification of the AC5 sensitization interactome using BiFCR21MH096927 · NIMH · PURDUE UNIVERSITY · PI DESSAUER, CARMEN W., HU, CHANG-DENG · 2013 to 2014
$436k
Understanding adaptive signaling of neuronal adenyly cyclases using siRNAR21MH101673 · NIMH · PURDUE UNIVERSITY · PI WATTS, VAL J · 2014 to 2014
$261k
NIMH NIH HHS R21 MH096927NIMH NIH HHS R21 MH101673NIMH NIH HHS R33 MH101673
6 · The paper itself

Abstract

Heterologous sensitization of adenylyl cyclase (AC) is revealed as enhanced or exaggerated AC/cAMP signaling that occurs following persistent activation of G

Indexed as

Adenylyl Cyclase InhibitorsAdenylyl CyclasesCarrier ProteinsCell SurvivalCullin ProteinsCyclic AMPCyclopentanesEnzyme ActivationGene Knockdown TechniquesGenome-Wide Association StudyHEK293 CellsHumansNEDD8 ProteinPyrimidinesReceptors, Dopamine D2RNA, Small InterferingAdenylyl Cyclase InhibitorsAdenylyl CyclasesCarrier ProteinsCUL3 protein, humanCullin ProteinsCULL-RING ligase, humanCyclic AMPCyclopentanesdopamine D2L receptorNEDD8 ProteinNEDD8 protein, humanpevonedistatPyrimidinesRBX1 protein, humanReceptors, Dopamine D2RNA, Small InterferingUbiquitin-Protein Ligases

Identifiers

PMID31857349
PMCPMC7011112
OpenAlexW2996640356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.