Evidence map›Paper›PMID 31857347›Full record

ArticleDevelopment (Cambridge, England)2020

Dosage-dependent requirements of

Charles J Sheehan, John J McMahon, Lucas D Serdar, Debra L Silver

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
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  7. DNA damage and repair: underlying mechanisms leading to microcephaly.Frontiers in cell and developmental biology · 2023
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Charles J SheehanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0001-9440-6519
John J McMahonDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0003-2426-1769
Lucas D SerdarDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-4574-1668
Debra L SilverDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA debra.silver@duke.edu.ORCID 0000-0001-9189-844X
Duke Medical Center · USDuke University · US

Funding

ORGANIZATION AND FUNCTIONS OF CELLULAR STRUCTUREST32GM007184 · NIGMS · DUKE UNIVERSITY · PI JINKS-ROBERTSON, SUE · 1985 to 2019
$18.2M
Mechanisms of neural progenitor division in the developing brainR01NS083897 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2013 to 2023
$3.4M
Distal mRNA localization and translation in neural stem cells of the developing brainR01NS110388 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2018 to 2022
$1.8M
Post-transcriptional RNA regulation in mammalian neural stem cellsR21NS098176 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2017 to 2018
$437k
Epitranscriptomic Control of Local Gene Expression in Neural Stem CellsR21MH119813 · NIMH · DUKE UNIVERSITY · PI MEYER, KATHRYN D, SILVER, DEBRA · 2019 to 2020
$435k
NIGMS NIH HHS T32 GM007184NIMH NIH HHS R21 MH119813NINDS NIH HHS R01 NS083897NINDS NIH HHS R01 NS110388NINDS NIH HHS R21 NS098176
6 · The paper itself

Abstract

Embryonic interneuron development underlies cortical function and its disruption contributes to neurological disease. Yet the mechanisms by which viable interneurons are produced from progenitors remain poorly understood. Here, we demonstrate dosage-dependent requirements of the exon junction complex component

Indexed as

AnimalsCell ProliferationCell SurvivalCerebral CortexGene Expression ProfilingImage Processing, Computer-AssistedInterneuronsMiceMitosisNeural Stem CellsNeurogenesisNuclear ProteinsSignal TransductionTumor Suppressor Protein p53Magoh protein, mouseNuclear ProteinsTrp53 protein, mouseTumor Suppressor Protein p53ApoptosisInterneuronMitosisMousep53ProgenitorRNA binding

Identifiers

PMID31857347
PMCPMC6983725
OpenAlexW2996459591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.