ArticleBMJ open2019
Does sex predict quality of life after acute coronary syndromes: an Australian, state-wide, multicentre prospective cohort study.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Effects of Interventions on Health-Related Quality of Life of People Living With Cardiovascular Disease: A Systematic Review.Journal of clinical nursing · 2025Pooled it
- Article
- Implementation of Early Mobilization in Post-CABG Patients: A Constructivist Grounded Theory Study.Patient preference and adherence · 2025Article
- Quality of Life in Patients Undergoing Percutaneous Coronary Intervention.Clinics and practice · 2023Article
- Article
- Responsiveness and minimal clinically important difference of EQ-5D-5L in patients with coronary heart disease after percutaneous coronary intervention: A longitudinal study.Frontiers in cardiovascular medicine · 2023Article
- Sex differences in quality of life of patients following percutaneous coronary intervention in Vietnam.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Article
- Sex differences in health-related quality of life trajectories following myocardial infarction: national longitudinal cohort study.BMJ open · 2022Article
- Sex Differences in Cardiac Rehabilitation Outcomes.Circulation research · 2022Review
- Sex-related differences in clinical outcomes and predictive factors in the very elderly patients with ACS undergoing PCI.Frontiers in cardiovascular medicine · 2022Article
- Effect of chronic unpredicted mild stress-induced depression on clopidogrel pharmacokinetics in rats.PeerJ · 2022Article
- SCAI Expert Consensus Statement on Sex-Specific Considerations in Myocardial Revascularization.Journal of the Society for Cardiovascular Angiography & InterventionsArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWomen have reported higher mortality and major adverse cardiovascular events (MACE) following acute coronary syndromes (ACSs) compared with men. With this in mind, we aimed to identify predictors of poor quality of life (QoL) post-ACS as our primary outcome. We examined predictors of MACE, major cerebrovascular events and major bleeding as our secondary outcome.
designProspective cohort study.
setting30 metropolitan centres across the Victorian Cardiac Outcomes Registry network.
participants16 517 patients treated with percutaneous coronary intervention (PCI) for ACS (22.9% females). Selection/inclusion criteria: consecutive patients with successful or attempted PCI for ACS from 2013 to 2016, alive at 30 days post-PCI. EXCLUSION CRITERIA: patients not fulfilling ACS criteria. At 30 days, 2497 (64.7% females) completed the QoL EQ-5D-3L instrument. PRIMARY AND SECONDARY OUTCOME MEASURES: QoL, assessed using the EuroQo-5Dimensions (EQ-5D-3L) instrument by telephone at 30 days. Independent predictors of QoL were identified by univariate and multivariate logistic regression analyses.
resultsWomen were significantly older with more diabetes, cerebrovascular disease and renal failure. Regarding the primary outcome, female sex was independently associated with moderate/severe impairment in all EQ-5D-3L domains including mobility (OR 2.38, 95% CI 2.06 to 2.75, p<0.001), personal care (OR 2.14, 95% CI 1.73 to 2.66, p<0.001), activities of daily living (OR 1.84, 95% CI 1.63 to 2.08, p<0.001), pain/discomfort (OR 1.44, 95% CI 1.24 to 1.67, p<0.001) and anxiety/depression (OR 1.49, 95% CI 1.30 to 1.70, p<0.001). Women had significantly lower self-rated Visual Analogue Scale scores (80.0 for both groups, IQR 60-85 vs 70-90, p<0.001). There was no significant difference between the sexes in secondary outcomes.
conclusionsFemale sex was a predictor of poorer QoL following PCI for ACS including significantly higher pain, anxiety and depression. This was independent of age, comorbidities and ACS presentation. There is a clinical need for a tailored approach in female ACS management, for example, emphasis on management of depressive and anxiety symptoms.
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