Evidence map›Paper›PMID 31857304›Full record

Observational studyBMJ open2019

Association of brain amyloidosis with the incidence and frequency of neuropsychiatric symptoms in ADNI: a multisite observational cohort study.

Naira Goukasian, Kristy S Hwang, Tamineh Romero, Jonathan Grotts, Triet M Do, Jenna R Groh, Daniel R Bateman, Liana G Apostolova

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. CSF proteome-wide study of neuropsychiatric symptoms of dementia.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Naira GoukasianRobert Larner College of Medicine, Burlington, Vermont, USA.ORCID 0000-0002-6765-2201
Kristy S HwangNeurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Tamineh RomeroMedicine Statistics Core, University of California Los Angeles, Los Angeles, California, USA.
Jonathan GrottsMedicine Statistics Core, University of California Los Angeles, Los Angeles, California, USA.
Triet M DoTulane University School of Medicine, New Orleans, Louisiana, USA.
Jenna R GrohNeurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Daniel R BatemanPsychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Liana G ApostolovaNeurology, Indiana University School of Medicine, Indianapolis, Indiana, USA lapostol@iu.edu.
Indiana University School of MedicineUniversity of California, Los Angeles · USEmory University · USTulane University · USUniversity of Vermont · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI APOSTOLOVA, LIANA G · 1991 to 2020
$37.3M
UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRILL, JOSHUA · 1999 to 2014
$25.9M
Imaging and genetic biomarkers for Alzheimer's diseaseR01AG040770 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI APOSTOLOVA, LIANA G · 2012 to 2016
$1.4M
Imaging epigenetics of Alzheimer's DiseaseK02AG048240 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI APOSTOLOVA, LIANA G · 2014 to 2016
$434k
NIA NIH HHS K02 AG048240NIA NIH HHS P30 AG010133NIA NIH HHS P50 AG016570NIA NIH HHS R01 AG040770NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

objectiveTo investigate the relationship between amyloid burden and frequency of existing and incidence of new neuropsychiatric symptoms (NPS) in elderly with and without cognitive decline.

methods275 cognitively normal controls (NC), 100 subjective memory complaint (SMC), 559 mild cognitive impairment (MCI) and 143 Alzheimer's disease dementia subjects from the Alzheimer's Disease Neuroimaging Initiative received (

resultsNo differences in NPS frequency were seen between amyloid positive and amyloid negative NC, SMC, MCI or dementia groups. MCI subjects with amyloid pathology however tended to have greater frequency x severity (FxS) of anxiety, hallucinations, delusions, apathy, disinhibition, irritability, aberrant motor behavior, and appetite, but not agitation, depression, night-time disturbances, or elation. MCI subjects with amyloid pathology were at greater risk for developing apathy, anxiety and agitation over time. Baseline presence of agitation and apathy and new onset agitation, irritability and apathy predicted faster conversion to dementia among MCI subjects.

conclusionsAmyloid pathology is associated with greater rate of development of new NPS in MCI. Anxiety and delusions are significant predictors of amyloid pathology. Agitation, irritability and apathy are significant predictors for conversion from MCI to dementia.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloidosisBehavioral SymptomsCase-Control StudiesCognitive DysfunctionDisease ProgressionHumansLongitudinal StudiesMagnetic Resonance ImagingPositron-Emission TomographyRisk FactorsSurveys and QuestionnairesAlzheimer’s disease (AD)Alzheimer’s Disease Neuroimaging Initiative (ADNI)AmyloidosisMild Cognitive Impairment (MCI)Neuropsychiatric Symptoms (NPS)

Identifiers

PMID31857304
PMCPMC6937083
OpenAlexW2995244706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.