Evidence map›Paper›PMID 31856753›Full record

ArticleBMC cancer2019

Fertility-sparing surgery and oncologic outcome among patients with early-stage ovarian cancer ~propensity score- matched analysis~.

Hiroaki Kajiyama, Shiro Suzuki, Nobuhisa Yoshikawa, Michiyasu Kawai, Kimio Mizuno, Osamu Yamamuro, Tetsuro Nagasaka, Kiyosumi Shibata, Fumitaka Kikkawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hiroaki KajiyamaDepartment of Obstetrics and Gynecology., Graduate School of Medicine, Nagoya University, Truma-cho 65, Showa-ku, Nagoya, 466-8550, Japan. kajiyama@med.nagoya-u.ac.jp.
Shiro SuzukiDepartment of Obstetrics and Gynecology., Graduate School of Medicine, Nagoya University, Truma-cho 65, Showa-ku, Nagoya, 466-8550, Japan.
Nobuhisa YoshikawaDepartment of Obstetrics and Gynecology., Graduate School of Medicine, Nagoya University, Truma-cho 65, Showa-ku, Nagoya, 466-8550, Japan.
Michiyasu KawaiDepartment of Obstetrics and Gynecology, Toyohashi Municipal Hospital, Toyohashi, Japan.
Kimio MizunoDepartment of Department of Obstetrics and Gynecology, Nagoya First Red-cross Hospital, Nagoya, Japan.
Osamu YamamuroDepartment of Obstetrics and Gynecology, Nagoya Second Red-cross Hospital, Nagoya, Japan.
Tetsuro NagasakaDivision of Medical Laboratory Sciences, School of Health Science, Nagoya University, Nagoya, Japan.
Kiyosumi ShibataDepartment of Obstetrics and Gynecology, Bantane Hospital, Fujita Health University, Nagoya, Japan.
Fumitaka KikkawaDepartment of Obstetrics and Gynecology., Graduate School of Medicine, Nagoya University, Truma-cho 65, Showa-ku, Nagoya, 466-8550, Japan.
Nagoya University · JPFujita Health University · JPNagoya City University · JPToyohashi Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate how much the risks of recurrence and death are increased as a consequence of selecting fertility-sparing surgery (FSS) in young women with epithelial ovarian cancer (EOC).

methodsAfter a central pathological review and search of the medical records from 14 collaborating hospitals, a non-randomized, observational cohort study was conducted between 1987 and 2015, including 1183 women with stage I EOC. Finally, a total of 285 patients with stage I EOC at reproductive age were recruited. Oncologic outcomes were compared between the FSS (N = 101) and radical surgery (RS) group (N = 184) using a propensity score (PS)-matching technique to adjust for relevant risk factors: the age, substage, histological type, grade, CA125 values, ascites cytology, ascites volume, and chemotherapy.

resultsDuring 66.0 months (median) of follow-up, 42 patients (14.7%) developed recurrence, and 31 patients (10.9%) died. In the original cohort, there was no significant difference in overall survival (OS) or recurrence-free survival (RFS) between the FSS and RS groups {Log-rank: OS (P = 0.838), RFS (P = 0.377)}. In the PS-matched cohort after adjustment for multiple clinicopathologic factors, there was no significant difference in RFS or OS between the FSS and RS groups {RFS (FSS vs. RS), HR: 1.262 (95% CI: 0.559-2.852), P = 0. 575; OS (FSS vs. RS), HR: 1.206 (95% CI: 0.460-3.163), P = 0.704}.

conclusionsAfter adjustment for clinicopathologic factors, FSS in itself may not worsen the oncologic outcome in young women with early-stage EOC. A large-scale clinical study is necessary to validate the findings.

Indexed as

AdultDisease-Free SurvivalFemaleFertility PreservationHumansMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingOvarian NeoplasmsPropensity ScoreRetrospective StudiesRiskSurvival RateEpithelial ovarian carcinomaFertility-sparing surgeryOverall survivalPropensity scoreRecurrenceRecurrence-free survival

Identifiers

PMID31856753
PMCPMC6921416
OpenAlexW2995638708

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.