ArticleBMC geriatrics2019
Impaired kidney function is associated with lower cognitive function in the elder general population. Results from the Good Aging in Skåne (GÅS) cohort study.
Article in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Dual Burden of Kidney Disease and Cognitive Impairment in the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia-Cohort.Kidney international reports · 2026Article
- Association between estimated glomerular filtration rate and memory function mediated by brain Gray matter volumes: a cross-sectional study using the ADNI database.BMC geriatrics · 2025Article
- Mental Health and Kidneys: The Interplay Between Cognitive Decline, Depression, and Kidney Dysfunction in Hospitalized Older Adults.Journal of clinical medicine · 2025Article
- Article
- Elevated pulse pressure preceded incident chronic kidney disease in the general older population in Sweden.Scientific reports · 2024Article
- Nomogram for predicting risk of mild renal dysfunction among general residents from rural Northeast China.Journal of translational internal medicine · 2024Article
- Article
- Chronic kidney disease and its association with cerebral small vessel disease in the general older hypertensive population.BMC nephrology · 2024Article
- Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults.International journal of geriatric psychiatry · 2022Article
- Prevalence and Correlates of Motoric Cognitive Risk Syndrome in Chinese Community-Dwelling Older Adults.Frontiers in aging · 2022Article
- Processing speed is affected by early impairment in kidney function in the general elder population.BMC nephrology · 2021Article
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4 authors.
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Abstract
backgroundA possible connection on vascular basis between impaired kidney function and cognitive dysfunction has been suggested in previous studies. Contradictory results regarding specific cognitive domains have been reported. The aim for this study was to investigate the association between kidney function and specific cognitive domains.
methodsIn this cross-sectional design, data from the general population based cohort study "Good aging in Skåne" (GÅS) was used. The sample included 2931 subjects ages 60 to 93 randomly selected from the southern part of Sweden. Estimated glomerular filtration rate (eGFR) for both creatinine and cystatine C was calculated using the chronic kidney disease epidemiology collaboration (CKD-EPI) equation. The subjects underwent a test battery of neuropsychological tests assessing global cognitive function, learning and memory, language, complex attention, executive function, perceptual motor and meta-memory. Adjustments were made for age, sex, education and country of origin.
resultsAfter adjustment for demographic variables, impaired kidney function was associated with 0.41 points worse result in MMSE, 0.56 points worse result in recognition, 0.66 points worse result in word fluency, 0.45 points worse result in digit cancellation, 0.99 points worse result in pattern comparison, and 3.71 s longer time to finish TMT B-A. Associations to cognitive function was also noted for mildly impaired kidney function defined as eGFR 45- < 60 ml/min/1,73m
conclusionsImpaired kidney function as well as the severity of impaired kidney function is associated with impairment in learning and memory, language, complex attention, executive function and global cognitive function, but not meta-memory.
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