Evidence map›Paper›PMID 31856677›Full record

ArticleCell cycle (Georgetown, Tex.)2020

Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway.

Daokun Yang, Xinwei Wang, Haili Gao, Baoxin Chen, Changyun Si, Shasha Wang

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71.Frontiers in cellular and infection microbiology · 2022
    Review
  10. Analysis of miRNAs Involved in Mouse Heart Injury Upon Coxsackievirus A2 Infection.Frontiers in cellular and infection microbiology · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daokun YangDepartment of Infectious Disease III, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Xinwei WangDepartment of Infectious Disease III, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Haili GaoDepartment of Infectious Disease III, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Baoxin ChenDepartment of Infectious Disease III, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Changyun SiDepartment of Infectious Disease III, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Shasha WangDepartment of Infectious Disease III, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
First Affiliated Hospital of Xinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterovirus 71 (EV71), the major cause of hand-foot-and-mouth disease (HFMD), has evolved diverse strategies to counter the type I interferon (IFN-I) response during infection. Recently, microRNAs have regulatory roles in host innate immune responses to viral infections; however, whether EV71 escapes the IFN-I antiviral response through regulation of miRNAs remains unclear. Using a microarray assay, microRNA-155-5p (miR-155-5p) was found to be significantly up-regulated in serum from patients with EV71 infection and the increased expression of miR-155-5p was further confirmed

Indexed as

Signal TransductionVirus ReplicationAnimalsBase SequenceCell LineDown-RegulationEnterovirusEnterovirus InfectionsForkhead Box Protein O3HumansInterferon Regulatory Factor-7Interferon Type IMice, Inbred C57BLMicroRNAsForkhead Box Protein O3FOXO3 protein, humanInterferon Regulatory Factor-7Interferon Type IIRF7 protein, humanMicroRNAsMIRN155 microRNA, humanEnterovirus 71FOXO3/IRF7 pathwaymiR-155-5p

Identifiers

PMID31856677
PMCPMC6961679
OpenAlexW2995778094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.