Evidence map›Paper›PMID 31856624›Full record

ArticleThe Journal of international medical research2020

Functional characteristics of autophagy in pancreatic cancer induced by glutamate metabolism in pancreatic stellate cells.

Lei Wang, RongRong Bi, Lei Li, Kun Zhou, HaiLin Liu

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Retraction.The Journal of international medical research · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lei WangDepartment of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
RongRong BiDepartment of Pulmonary, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-2731-5013
Lei LiDepartment of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
Kun ZhouDepartment of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
HaiLin LiuDepartment of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
Shanghai Ninth People's Hospital · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the effects of glutaminase (GLS) inhibitors on autophagy and proliferation of pancreatic stellate cells, and to explore their functions in pancreatic cancer.

methodsPancreatic cancer cells were divided into two groups. Group A was the control untreated group, and group B cells were treated with GLS inhibitors. Western blotting was used to detect the expression of Atg5, Bcl-2, Bax, and Bid proteins. The bromodeoxyuridine assay and scratch test were employed to investigate cell proliferation and invasion, respectively. The expression of E-cadherin, vimentin, cell adhesion molecule 2 (CADM2), and Snail protein was investigated by immunofluorescence.

resultsThe expression of Atg5, Bax, and Bid was higher in group A than in group B, while Bcl-2 expression was lower in group A than in group B. Group A cells demonstrated greater proliferation and invasion than group B cells. The expression of E-cadherin was lower in group A cells than group B cells, while vimentin, CADM2, and Snail were expressed at higher levels in group A than group B cells.

conclusionThe inhibition of glutamine isozymes reduces autophagy and apoptosis in astrocytes, and inhibits pancreatic cancer cell proliferation and metastasis, while reducing their invasiveness.

Indexed as

Pancreatic NeoplasmsPancreatic Stellate CellsApoptosisAutophagyCell Line, TumorCell MovementCell ProliferationGlutamatesHumansGlutamatesAutophagycell adhesion molecule 2glutamate metabolismglutaminasepancreatic cancerpancreatic stellate cells

Identifiers

PMID31856624
PMCPMC7607760
OpenAlexW2995568109

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.