ArticleThe Journal of physiology2020
Determinants of the diminished exercise capacity in patients with chronic obstructive pulmonary disease: looking beyond the lungs.
Article in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Automatically titrating oxygen system versus constant flow oxygen system during exercise in patients with COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Comparing effects of breathing exercises alone and combined with breathing-stretching exercises on respiratory indices, disease severity and exercise capacity in COPD.Scientific reports · 2025Trial
- Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD.Therapeutic advances in respiratory diseaseTrial
- Exercise intolerance and impaired aerobic capacity in heart transplant recipients.Experimental physiology · 2026Review
- Evidence that myoglobin PoFunction (Oxford, England) · 2026Article
- Haemodynamic responses to small muscle mass exercise before and after lung transplantation in end-stage chronic obstructive pulmonary disease.Experimental physiology · 2026Article
- Sarcopenia and Frailty in COPD: Mechanisms, Relationship with Malnutrition and Potential Therapeutic Interventions.Nutrients · 2026Review
- Muscle fibre type shift in COPD: Adaptive, maladaptive or a bit of both?Experimental physiology · 2026Article
- Raclet: the ramp above critical level endurance test to evaluate critical force in isometric task.European journal of applied physiology · 2026Article
- Test-retest reliability of Doppler ultrasound-based leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease.Experimental physiology · 2026Article
- Near-Infrared Spectroscopy in the Pathophysiology, Diagnosis, and Exercise-Based Management of Muscle Oxygenation Impairment.Diagnostics (Basel, Switzerland) · 2026Review
- Small muscle mass aerobic exercise in health and disease: Unique insights into muscle vascular and metabolic control and performance.Experimental physiology · 2026Review
- Advances in gas-exchange physiology and pathophysiology.ERS monograph · 2025Article
- Understanding Chronic Obstructive Pulmonary Disease Management and Treatment Patterns in General Medicine: Results From the ASTER Study in Italy.International journal of chronic obstructive pulmonary disease · 2025Observational
- Overdot and overline annotation must be understood to accurately interpretFrontiers in physiology · 2024Article
- Determinants of maximal oxygen consumption.Journal of muscle research and cell motility · 2023Article
- Sympathetic Neural Overdrive, Aortic Stiffening, Endothelial Dysfunction, and Impaired Exercise Capacity in Severe COVID-19 Survivors: A Mid-Term Study of Cardiovascular Sequelae.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Skeletal Muscle Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease: Underlying Mechanisms and Physical Therapy Perspectives.Aging and disease · 2023Article
- Utility of Cardiopulmonary Exercise Testing in Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2023Review
- Plasma ratio of angiopoietin-2 to angiopoietin-1 is a biomarker of vascular impairment in chronic obstructive pulmonary disease patients.Angiogenesis · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
key pointsPeak oxygen uptake, a primary determinant of prognosis, mortality and quality of life, is diminished in patients with chronic obstructive pulmonary disease (COPD), with mounting evidence supporting an important role for peripheral dysfunction, particularly within skeletal muscle. In patients with severe COPD and activity-matched controls, muscle oxygen transport and utilization were assessed at peak effort during single-leg knee-extensor exercise (KE), where ventilation is assumed to be submaximal. This strategy removes ventilation as the major constraint to exercise capacity in COPD, allowing maximal muscle function to be attained and evaluated. During maximal KE, both convective arterial oxygen delivery to the skeletal muscle microvasculature and subsequent diffusive oxygen delivery to the mitochondria were diminished in patients with COPD compared to control subjects. These findings emphasize the importance of factors, beyond the lungs, that influence exercise capacity in this patient population and may, ultimately, influence the prognosis, mortality and quality of life for patients with COPD. ABSTRACT: Peak oxygen uptake (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.