ReviewChinese medical journal2019
Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review.
Review in Chinese medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Bibliometrics analysis on the research status and trends of adult-onset Still's disease: 1921-2021.Frontiers in immunology · 2022Pooled it
- Urinary Proteomics Identifying Novel Biomarkers for the Diagnosis of Adult-Onset Still's Disease.Frontiers in immunology · 2020Trial
- Delayed Diagnosis: Adult-Onset Still's Disease Initially Mistaken for Tuberculosis in a Nigerian Man.Cureus · 2026Article
- Tocilizumab combined with short-term high-dose glucocorticoids for rapid disease activity control and glucocorticoid reduction in adult-onset Still's disease: a single-center retrospective study.Frontiers in immunology · 2026Article
- TLR9 decreases FOXO3 expression to prevent excessive inflammation in macrophage activation syndrome.iScience · 2025Article
- Coexistence of Adult-Onset Still's Disease and Graves' Disease: Coincidence or Continuum?Cureus · 2025Article
- Challenges on diagnosis and treatment of refractory adult-onset still disease in Sub-Saharan Africa: a case report.Journal of medical case reports · 2025Article
- Contribution to the debate on the origin of autoimmune joint diseases in Europe through an archaeological case of still's disease.Scientific reports · 2025Article
- High Neutrophil Alkaline Phosphatase Activity in Adult-Onset Still's Disease.Rheumatology and therapy · 2025Article
- The diagnostic dilemma of adult-onset Still's disease: a case report.Annals of medicine and surgery (2012) · 2025Article
- Diagnostic Dilemma: Adult Onset Still's Disease Mimicking Lymphoma-A Case Report and Literature Review.Case reports in immunology · 2025Article
- Associations between circulating interleukin-18 levels and adult-onset Still's disease: a meta-analysis.Journal of rheumatic diseases · 2025Article
- Article
- Multiorgan Dysfunction in a Patient With Adult-Onset Still's Disease Flare: A Case Report.Cureus · 2024Article
- Association between adult-onset still's disease and COVID-19: A report of two cases and brief review.SAGE open medical case reports · 2024Article
- Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still's disease.BMC medicine · 2023Article
- Persistent Pancytopenia as a Long-COVID Manifestation in a Patient with Adult-Onset Still's Disease: A Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- Adult-Onset Still's Disease (AOSD) Associated With Collagenous Colitis (CC) and Basedow's Disease: A Case Report.Cureus · 2023Article
- Proposal of a new diagnostic algorithm for adult-onset Still's disease.Clinical rheumatology · 2023Article
- A Streamlined Diagnostic Process Improved the Outcomes of Patients with Adult-Onset Still's Disease: A Single-Center Retrospective Observational Study.Rheumatology and therapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAdult-onset Still's disease (AOSD) is a rare but clinically well-known polygenic systemic autoinflammatory disease. In this review, we aim to present frontiers in the pathogenesis, clinical features, diagnosis, biomarkers, disease course, prognosis, and treatment in AOSD. DATA SOURCES: We retrieved information from the PubMed database up to July 2019, using various search terms and relevant words, including AOSD and Still's disease. STUDY SELECTION: We included data from peer-reviewed journals. Both basic and clinical studies were selected.
resultsPathogenesis of AOSD involves genetic background, infectious triggers, and immunopathogenesis, mainly the activation of macrophages and neutrophils followed by a cytokine storm. Diagnosis and prognosis evaluation of AOSD is still challenging; therefore, there is an urgent need to identify better biomarkers. Biologic agents, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α antagonists in the treatment of AOSD, have good prospect.
conclusionThis review highlights the advances in pathogenesis, potential biomarkers, disease course, and treatment in AOSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.