ArticleSleep2020
Onset of regular cannabis use and young adult insomnia: an analysis of shared genetic liability.
Article in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Sleep quality of adult recreational cannabis users: a systematic review of literature.Trends in psychiatry and psychotherapy · 2025Pooled it
- Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.Journal of adolescence · 2026Article
- The impact of sleep problems on cerebral aneurysm risk is mediated by hypertension: a mediated Mendelian randomization study.Frontiers in genetics · 2024Article
- A Review of the Effects of Adolescent Cannabis Use on Physical Health.The Psychiatric clinics of North America · 2023Review
- Sub-types of insomnia in adolescents: Insights from a quantitative/molecular twin study.JCPP advances · 2023Article
- A Review of the Effects of Adolescent Cannabis Use on Physical Health.Child and adolescent psychiatric clinics of North America · 2023Review
- Associations between specific sleep and circadian characteristics and alcohol use disorder criteria and problems.Addictive behaviors · 2022Article
- Characterisation of the genetic relationship between the domains of sleep and circadian-related behaviours with substance use phenotypes.Addiction biology · 2022Article
- Sleep and alertness disturbance and substance use disorders: A bi-directional relation.Pharmacology, biochemistry, and behavior · 2021Review
- Article
- Twin studies of brain, cognition, and behavior.Neuroscience and biobehavioral reviews · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesEstimate the genetic and environmental influences on the relationship between onset of regular cannabis use and young adult insomnia.
methodsIn a population-based twin cohort of 1882 twins (56% female, mean age = 22.99, SD = 2.97) we explored the genetic/environmental etiology of the relationship between onset of regular cannabis use and insomnia-related outcomes via multivariate twin models.
resultsControlling for sex, current depression symptoms, and prior diagnosis of an anxiety or depression disorder, adult twins who reported early onset for regular cannabis use (age 17 or younger) were more likely to have insomnia (β = 0.07, p = 0.024) and insomnia with short sleep on weekdays (β = 0.08, p = 0.003) as young adults. We found significant genetic contributions for the onset of regular cannabis use (a2 = 76%, p < 0.001), insomnia (a2 = 44%, p < 0.001), and insomnia with short sleep on weekdays (a2 = 37%, p < 0.001). We found significant genetic correlations between onset of regular use and both insomnia (rA = 0.20, p = 0.047) and insomnia with short sleep on weekdays (rA = 0.25, p = 0.008) but no significant environmental associations between these traits.
conclusionsWe found common genetic liabilities for early onset of regular cannabis use and insomnia, implying pleiotropic influences of genes on both traits.
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