Evidence map›Paper›PMID 31855161›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019

Effects of a Tailored Lighting Intervention on Sleep Quality, Rest-Activity, Mood, and Behavior in Older Adults With Alzheimer Disease and Related Dementias: A Randomized Clinical Trial.

Mariana G Figueiro, Barbara Plitnick, Charles Roohan, Levent Sahin, Michael Kalsher, Mark S Rea

3 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 61 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 9 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01816152 nacompletednot on this mapstarted 2020, after this paper: background citation

Phase 1 Methodology Issues in a Tailored Light Treatment for Persons With Dementia

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2020 to 2024Enrolled44ConditionsSleep Disturbances, DepressionArmsHigh Active intervention, Inactive intervention, Mid Level Active Intervention
NCT05246332 nacompletednot on this map

Grounding the Body Improves Sleep Quality in Patients With Mild Alzheimer's Disease

TypeinterventionalSponsorChang Gung Memorial HospitalRan2019 to 2020Enrolled22ConditionsAlzheimer Disease, Insomnia, Depression, AnxietyArmsGrounding
NCT05825404 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effect of Smart Ambient Bright Light for Nursing Home Residents With Alzheimer's Disease and Related Dementias

TypeinterventionalSponsorPenn State UniversityRan2023 to 2023Enrolled51ConditionsAlzheimer's Disease and Related DementiasArmsSmart Ambient Bright Light (SABL), Control
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 9 syntheses or guidelines pooled it, 113 citations in OpenAlex.

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  12. Home-Based Tailored Light Therapy for Sleep, Mood, and Cognitive Outcomes in Mild Cognitive Impairment: A Randomized Trial.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mariana G FigueiroLighting Research Center, Rensselaer Polytechnic Institute, Troy, New York, United States.
Barbara PlitnickLighting Research Center, Rensselaer Polytechnic Institute, Troy, New York, United States.
Charles RoohanLighting Research Center, Rensselaer Polytechnic Institute, Troy, New York, United States.
Levent SahinLighting Research Center, Rensselaer Polytechnic Institute, Troy, New York, United States.
Michael KalsherCognitive Science Department, School of Humanities, Arts and Social Sciences, Rensselaer Polytechnic Institute, Troy, New York, United States.
Mark S ReaLighting Research Center, Rensselaer Polytechnic Institute, Troy, New York, United States.
Rensselaer Polytechnic Institute · US

Funding

Methodology Issues in a Tailored Light Treatment for Persons with DementiaR01AG034157 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI FIGUEIRO, MARIANA GROSS · 2010 to 2024
$7.9M
NIA NIH HHS R01 AG034157
6 · The paper itself

Abstract

STUDY

objectivesWe investigated the effectiveness of a lighting intervention tailored to maximally affect the circadian system as a nonpharmacological therapy for treating problems with sleep, mood, and behavior in persons with Alzheimer disease and related dementias (ADRD).

methodsThis 14-week randomized, placebo-controlled, crossover design clinical trial administered an all-day active or control lighting intervention to 46 patients with ADRD in 8 long-term care facilities for two 4-week periods (separated by a 4-week washout). The study employed wrist-worn actigraphy measures and standardized measures of sleep quality, mood, and behavior.

resultsThe active intervention significantly improved Pittsburgh Sleep Quality Index scores compared to the active baseline and control intervention (mean ± SEM: 6.67 ± 0.48 after active intervention, 10.30 ± 0.40 at active baseline, 8.41 ± 0.47 after control intervention). The active intervention also resulted in significantly greater active versus control differences in intradaily variability. As for secondary outcomes, the active intervention resulted in significant improvements in Cornell Scale for Depression in Dementia scores (mean ± SEM: 10.30 ± 1.02 at baseline, 7.05 ± 0.67 after active intervention) and significantly greater active versus control differences in Cohen-Mansfield Agitation Inventory scores (mean ± SEM: -5.51 ± 1.03 for the active intervention, -1.50 ± 1.24 for the control intervention).

conclusionsA lighting intervention tailored to maximally entrain the circadian system can improve sleep, mood, and behavior in patients with dementia living in controlled environments. CLINICAL

trial registrationRegistry: ClinicalTrials.gov, title: Methodology Issues in a Tailored Light Treatment for Persons With Dementia, URL: https://clinicaltrials.gov/ct2/show/NCT01816152, identifier: NCT01816152.

Indexed as

ActigraphyActivities of Daily LivingAged, 80 and overAlzheimer DiseaseCircadian RhythmCross-Over StudiesDementiaFemaleGeriatric AssessmentHumansLightingMaleMood DisordersPhototherapyPsychomotor AgitationSleep Wake DisordersAlzheimer’s diseasecircadian systemdementialighting interventionmoodrest–activitysleep

Identifiers

PMID31855161
PMCPMC7099185
OpenAlexW2991516029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.