ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019
Cardiovascular Effect and Symptom Profile of Obstructive Sleep Apnea: Does Sex Matter?
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- OSA and Acute Coronary Syndrome Severity: The Potential Role of Coronary Collateral Circulation.Chest · 2026Trial
- Advances in the Diagnosis and Treatment of Obstructive Sleep Apnea in Women.Pulmonary therapy · 2026Review
- Insomnia, Sleep Apnea, and Incidence of Hypertension and Cardiovascular Disease Among Men and Women US Veterans.Journal of the American Heart Association · 2025Article
- Gender differences in obstructive sleep apnea syndrome: a pilot study.Sleep & breathing = Schlaf & Atmung · 2024Article
- Association of Sex With Cardiovascular Outcomes in Heart Failure Patients With Obstructive or Central Sleep Apnea.Journal of the American Heart Association · 2024Observational
- Mild obstructive sleep apnoea in females:ERJ open research · 2024Article
- Association of obstructive sleep apnoea with cardiovascular events in women and men with acute coronary syndrome.The European respiratory journal · 2023Article
- Gender-related sleep duration perception in a Brazilian sleep clinic cohort.Sleep & breathing = Schlaf & Atmung · 2022Article
- Self-Reported Sleep Characteristics Associated with Cardiovascular Disease Among Older Adults Living in Rural Eastern China: A Population-Based Study.Clinical interventions in aging · 2022Article
- Smoking and Obstructive Sleep Apnea: Is There An Association between These Cardiometabolic Risk Factors?-Gender Analysis.Medicina (Kaunas, Lithuania) · 2021Article
- Gender Issues in Obstructive Sleep Apnea.The Yale journal of biology and medicine · 2021Review
- Increased prevalence of obstructive sleep apnea in women diagnosed with endometrial or breast cancer.PloS one · 2021Article
- Evaluation of Obstructive Sleep Apnea in Female Patients in Primary Care: Time for Improvement?Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Review
- An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment.Frontiers in cardiovascular medicine · 2021Review
- [Deterioration of gas exchange in subjects with an increase in body mass index at an altitude of 2,240 meters above sea level].Archivos de cardiologia de Mexico · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo evaluate the influence of sex on obstructive sleep apnea (OSA)-related symptoms and prevalent cardiovascular disease (CVD) in a large clinical population of patients.
methodsA total of 6,716 patients (mean age 52 years, 24% women) had undergone diagnostic polysomnography and completed the Epworth Sleepiness Scale (ESS), Athens Insomnia Scale, and Beck Depression Inventory. We investigated the predictive value of sex on associated symptoms and prevalent cardiovascular disease, after adjustment for relevant confounding factors including age, obesity, and comorbidities.
resultsMost of the patients (90%) had OSA (apnea-hypopnea index [AHI] ≥ 5 events/h), and 66% were obese. Women were older than men and had a higher body mass index; however, men had a thicker neck circumference, a higher waist-to-hip ratio, and increased OSA severity (AHI 36 versus 27 events/h, P < .001). Female sex independently predicted prevalent CVD after adjustment for confounders (odds ratio [95% CI] 1.476 [1.154-1.887], P = .002). Men independently were more likely to report driving problems (3.359 [2.470-4.569], P < .001) and excessive daytime sleepiness (ESS ≥ 16) (1.355 [1.036-1.773], P = .027). Furthermore, female sex was an independent predictive factor for depressive symptoms (2.473 [1.831-3.340], P < .001), frequent awakenings (1.703 [1.323-2.192], P < .001), nocturia (1.727 [1.340-2.226], P < .001) and morning headaches (1.855 [1.488-2.326], P < .001).
conclusionsFemales referred for sleep studies were more likely to exhibit CVD and less likely to complain of typical OSA symptoms than males in this large clinical patient cohort.
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