Trial reportBlood transfusion = Trasfusione del sangue2020
D-dimer corrected for thrombin and plasmin generation is a strong predictor of mortality in patients with sepsis.
Trial report in Blood transfusion = Trasfusione del sangue, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The association between coagulation function and prognosis in patients with sepsis: a meta-analysis of predictive performance introduction.Frontiers in medicine · 2025Pooled it
- COVID-19 and haemostasis: a position paper from Italian Society on Thrombosis and Haemostasis (SISET).Blood transfusion = Trasfusione del sangue · 2020Guideline
- Interpretable machine learning for early prediction of sepsis-induced coagulopathy: a multicenter retrospective development and validation study.BMC medical informatics and decision making · 2026Article
- Exploratory Analysis of Coagulation and Fibrinolysis Trajectories After IL-6 Antagonist Therapy in COVID-19: A Case Series.Biomedicines · 2026Article
- The Fibrinolytic System in Bacterial Sepsis: A Comprehensive Review of Current Assessment Methods.Journal of clinical medicine · 2025Review
- Update of the sequential organ failure assessment score: current status and challenges?Frontiers in medicine · 2025Review
- Development and validation of a nomogram for predicting sepsis in patients with pyogenic liver abscess.Scientific reports · 2023Article
- Monitoring the Coagulation Profile of COVID-19 Patients Using Standard and ClotProMedicina (Kaunas, Lithuania) · 2023Article
- A Nomogram-Based Model for Predicting the Risk of Severe Acute Cholangitis Occurrence.International journal of general medicine · 2023Article
- Increased thrombin activatable fibrinolysis inhibitor activity is associated with hypofibrinolysis in dogs with sepsis.Frontiers in veterinary science · 2023Article
- Review
- Prognostic value of PaOThe Journal of international medical research · 2022Article
- Antimicrobial Susceptibility Characteristics and Risk Factors Associated with Adult Sepsis in Wenzhou, China.Infection and drug resistance · 2022Article
- Expression and Significance of D-Dimer and Fibrinogen in Hyperfibrinolysis of Elderly Patients with Bleeding after BPH Operation.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The Diagnostic Value of FeTherapeutics and clinical risk management · 2021Article
- Prognostic Value of Albumin to D-Dimer Ratio in Advanced Gastric Cancer.Journal of oncology · 2021Article
- The Prothrombotic State Associated with SARS-CoV-2 Infection: Pathophysiological Aspects.Mediterranean journal of hematology and infectious diseases · 2021Review
- Study on the Clinical Significance of ACE2 and Its Age-Related Expression.Journal of inflammation research · 2021Article
- COVID-19, coagulopathy and venous thromboembolism: more questions than answers.Internal and emergency medicine · 2020Review
- Immune dysfunction following COVID-19, especially in severe patients.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundD-dimer (DD) is the most used fibrin-related marker and has been proposed, either alone or in combination with other variables, as prognostic factor in patients with sepsis. However, DD generation depends on both coagulation and fibrinolysis, meaning that it may give false negative results in conditions associated with marked fibrinolytic inhibition such as sepsis. In this study, we tested whether correction of DD for thrombin and plasmin generation could improve its prognostic significance in septic patients. MATERIAL AND
methodsWe performed a nested study in 269 septic patients from the ALBIOS trial. DD, prothrombin fragment 1+2 (F1+2) and plasmin-antiplasmin complex (PAP) were assayed at day 1. Corrected DD (DD
resultsDD DISCUSSION: DD
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.