Trial reportMovement disorders : official journal of the Movement Disorder Society2020
Little Change in Functional Brain Networks Following Acute Levodopa in Drug-Naïve Parkinson's Disease.
Trial report in Movement disorders : official journal of the Movement Disorder Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Functional Connectivity and Volumetrics Improve Outcome Prediction for Deep Brain Stimulation in Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Functional and structural gradients reveal atypical hierarchical organization of Parkinson's disease.Human brain mapping · 2024Article
- Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2024Article
- Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease.bioRxiv : the preprint server for biology · 2023Article
- Article
- Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease.NeuroImage · 2022Article
- Covariance and Correlation Analysis of Resting State Functional Magnetic Resonance Imaging Data Acquired in a Clinical Trial of Mindfulness-Based Stress Reduction and Exercise in Older Individuals.Frontiers in neuroscience · 2022Article
- Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Structural MRI substrate of long-duration response to levodopa in Parkinson's disease: an exploratory study.Journal of neurology · 2021Article
- Resting-state functional connectivity associated with gait characteristics in people with Parkinson's disease.Behavioural brain research · 2021Article
- Resting-State Functional Connectivity Predicts STN DBS Clinical Response.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Global motion detection and censoring in high-density diffuse optical tomography.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe objective of this study was to investigate the effects of levodopa on functional brain networks in Parkinson's disease.
methodsWe acquired resting state functional magnetic resonance imaging in 30 drug-naïve participants with Parkinson's disease and 20 age-matched healthy controls. Each participant was studied following administration of a single oral dose of either levodopa or placebo in a randomized, double-blind, crossover design.
resultsThe greatest observed differences in functional connectivity were between Parkinson's disease versus control participants, independent of pharmacologic intervention. By contrast, the effects of levodopa were much smaller and detectable only in the Parkinson's disease group. Moreover, although levodopa administration in the Parkinson's disease group measurably improved motor performance, it did not increase the similarity of functional connectivity in Parkinson's disease to the control group.
conclusionsWe found that a single, small dose of levodopa did not normalize functional connectivity in drug-naïve Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.