Evidence map›Paper›PMID 31854002›Full record

ArticleArtificial organs2020

Evaluation of an autoregulatory ECMO system for total respiratory support in an acute ovine model.

Robert G Conway, Zachary B Berk, Jiafeng Zhang, Tieluo Li, Douglas Tran, Zhongjun J Wu, Bartley P Griffith

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Artificial organs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Wearable Extracorporeal COBioengineering (Basel, Switzerland) · 2024
    Article
  5. Review
  6. A Portable Servoregulation Controller to Automate COBioengineering (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Robert G ConwayDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-6836-9432
Zachary B BerkDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Jiafeng ZhangDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Tieluo LiDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Douglas TranDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Zhongjun J WuDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-0807-7195
Bartley P GriffithDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · US

Funding

First-in-Human Use of an Artificial Lung for Ambulatory Respiratory SupportR01HL118372 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P, WU, ZHONGJUN JON · 2013 to 2023
$7.9M
Development and Pre-Clinical Trial Qualification of a Pediatric Pump-Lung System for ChildrenR01HL141817 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P, WU, ZHONGJUN JON · 2018 to 2021
$3.1M
NHLBI NIH HHS R01 HL118372NHLBI NIH HHS R01HL118372NHLBI NIH HHS R01 HL141817NHLBI NIH HHS R01HL141817
6 · The paper itself

Abstract

Extracorporeal membrane oxygenation (ECMO) has become a mainstay of therapy for patients suffering from severe respiratory failure. Ambulatory ECMO systems aim to provide long-term out-of-hospital respiratory support. As a patient's activity level changes, the required level of ECMO support varies with oxygen consumption and metabolic fluctuations. To compensate for such changes, an autoregulatory ECMO system (AR-ECMO) has been developed and its performance was evaluated as a proof of concept in an acute ovine model. The AR-ECMO system consists of a regular ECMO circuit and an electromechanical control system. A custom fuzzy logic control algorithm was implemented to adjust the blood flow and sweep gas flow of the ECMO circuit to meet the varying respiratory demand by utilizing two noninvasive sensors for venous oxyhemoglobin saturation and the oxygenator exhaust gas CO

Indexed as

AnimalsExtracorporeal Membrane OxygenationFuzzy LogicMaleSheepartificial lungautoregulatory controlextracorporeal membrane oxygenationrespiratory distress

Identifiers

PMID31854002
PMCPMC7165054
OpenAlexW2995317964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.