Evidence map›Paper›PMID 31853975›Full record

ArticleMedical physics2020

Multimodality image registration in the head-and-neck using a deep learning-derived synthetic CT as a bridge.

Elizabeth M McKenzie, Anand Santhanam, Dan Ruan, Daniel O'Connor, Minsong Cao, Ke Sheng

Abstract read
In one paragraph

Article in Medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. A universal medical imaging modality translation model in brain and head-and-neck radiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
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  14. Article
  15. A transformer-based hierarchical registration framework for multimodality deformable image registration.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2023
    Article
  16. Article
  17. Article
  18. Abdominopelvic MR to CT registration using a synthetic CT intermediate.Journal of applied clinical medical physics · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth M McKenzieDepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Anand SanthanamDepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Dan RuanDepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Daniel O'ConnorDepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Minsong CaoDepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Ke ShengDepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90024, USA.

Funding

Development of a versatile robotic radiation therapy systemR44CA183390 · NCI · RADIABEAM TECHNOLOGIES, LLC · PI SHENG, KE, YONEMOTO, JAY · 2017 to 2024
$5.8M
Motion Management of Pancreatic Cancer in MRI-Guided RadiotherapyR01CA188300 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHENG, KE · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA188300NCI NIH HHS R44 CA183390NIH HHS R01CA188300NIH HHS R44CA183390
6 · The paper itself

Abstract

purposeTo develop and demonstrate the efficacy of a novel head-and-neck multimodality image registration technique using deep-learning-based cross-modality synthesis. METHODS AND MATERIALS: Twenty-five head-and-neck patients received magnetic resonance (MR) and computed tomography (CT) (CT

resultsWhen large initial rigid misalignment is present, registering CT to MRI-derived synthetic CT aligns the cord better than a direct registration. The average landmark error decreased from 9.8 ± 3.1 mm in MR→CT

conclusionsWe showed that using a deep learning-derived synthetic CT in lieu of an MR for MR→CT and CT→MR deformable registration offers superior results to direct multimodal registration.

Indexed as

Deep LearningTomography, X-Ray ComputedHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMultimodal Imagingdeep learningmulti-modal registrationsynthetic CT

Identifiers

PMID31853975
PMCPMC7067662

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.