Evidence map›Paper›PMID 31853810›Full record

ArticleInternational journal of hematology2020

Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells.

Behnam Sadeghi, Bo Ersmark, Gianluca Moretti, Jonas Mattsson, Olle Ringdén

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in International journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Behnam SadeghiTranslational Cell Therapy Research (TCR), Department of Clinical Science, Intervention and Technology, Karolinska Institutet, KFC, NOVUM, Plan 6, Karolinska University Hospital Huddinge, Hälsovägen 7, 141 57, Huddinge, Sweden. behnam.sadeghi@ki.se.ORCID http://orcid.org/0000-0002-8721-0400
Bo ErsmarkDepartment of Neurology, Queen Sofias Hospital, Stockholm, Sweden.
Gianluca MorettiTranslational Cell Therapy Research (TCR), Department of Clinical Science, Intervention and Technology, Karolinska Institutet, KFC, NOVUM, Plan 6, Karolinska University Hospital Huddinge, Hälsovägen 7, 141 57, Huddinge, Sweden.
Jonas MattssonDepartment of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Olle RingdénTranslational Cell Therapy Research (TCR), Department of Clinical Science, Intervention and Technology, Karolinska Institutet, KFC, NOVUM, Plan 6, Karolinska University Hospital Huddinge, Hälsovägen 7, 141 57, Huddinge, Sweden.
Karolinska University Hospital · SE

Funding

Barncancerfonden PR2013-0045Cancerfonden CAN2013/671Cancerföreningen i Stockholm 111293Vetenskapsrådet K2014-64X-05971-34-4
6 · The paper itself

Abstract

Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patients with radiculomyelopathy. The first patient was a 73-year old man treated with parotidectomy and irradiation for lymphoma of the neck. Following a Yersinia infection, he developed a radiculomyelopathy in C3/C4 and could not elevate his arms. The second patient was a 34-year old woman who was admitted 8 months after allogeneic hematopoietic stem cell transplantation due to hemolysis, impaired sensorium below arcus, and difficulty in ambulation. Following intravenous infusion of DSCs (1 × 10

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationAdultAgedDeciduaFemaleHumansMalePlacentaPregnancyRadiculopathySpinal Cord DiseasesTreatment OutcomeDecidua stromal cellsGraft-versus-host diseaseMesenchymal stromal cellsMyelopathy

Identifiers

PMID31853810
PMCPMC7102257
OpenAlexW2995092850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.