Evidence map›Paper›PMID 31853774›Full record

ArticleMedical & biological engineering & computing2020

Implantable electrical stimulation bioreactor with liquid crystal polymer-based electrodes for enhanced bone regeneration at mandibular large defects in rabbit.

Chaebin Kim, Hoon Joo Yang, Tae Hyung Cho, Beom Seok Lee, Tae Mok Gwon, Soowon Shin, In Sook Kim, Sung June Kim, Soon Jung Hwang

Abstract read
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In one paragraph

Article in Medical & biological engineering & computing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. The application of impantable sensors in the musculoskeletal system: a review.Frontiers in bioengineering and biotechnology · 2024
    Review
  2. Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Chaebin KimDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.
Hoon Joo YangDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Tae Hyung ChoDental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Beom Seok LeeDental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Tae Mok GwonDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.
Soowon ShinDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.
In Sook KimDental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Sung June KimDepartment of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea. kimsj@snu.ac.kr.
Soon Jung HwangDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Seoul National University · KRSeoul National University Dental Hospital · KR

Funding

Defense Acquisition Program Administration UD170030IDSchool of Dentistry and College of Engineering, Seoul National University Dentistry - Engineering Interdisciplinary Research Grant
6 · The paper itself

Abstract

The osseous regeneration of large bone defects is still a major clinical challenge in maxillofacial and orthopedic surgery. Previous studies demonstrated that biphasic electrical stimulation (ES) stimulates bone formation; however, polyimide electrode should be removed after regeneration. This study presents an implantable electrical stimulation bioreactor with electrodes based on liquid crystal polymer (LCP), which can be permanently implanted due to excellent biocompatibility to bone tissue. The bioreactor was implanted into a critical-sized bone defect and subjected to ES for one week, where bone regeneration was evaluated four weeks after surgery using micro-CT. The effect of ES via the bioreactor was compared with a sham control group and a positive control group that received recombinant human bone morphogenetic protein (rhBMP)-2 (20 μg). New bone volume per tissue volume (BV/TV) in the ES and rhBMP-2 groups increased to 132% (p < 0.05) and 174% (p < 0.01), respectively, compared to that in the sham control group. In the histological evaluation, there was no inflammation within the bone defects and adjacent to LCP in all the groups. This study showed that the ES bioreactor with LCP electrodes could enhance bone regeneration at large bone defects, where LCP can act as a mechanically resistant outer box without inflammation. Graphical abstract To enhance bone regeneration, a bioreactor comprising collagen sponge and liquid crystal polymer-based electrode was implanted in the bone defect. Within the defect, electrical current pulses having biphasic waveform were applied from the implanted bioreactor.

Indexed as

BioreactorsAnimalsBone RegenerationCancellous BoneElectric StimulationElectrodesMaleMandibleOsteogenesisPolymersRabbitsX-Ray Microtomographyliquid crystal polymerPolymersBone regenerationElectrical stimulationImplantable bioreactorLarge bone defectLiquid crystal polymer

Identifiers

PMID31853774
OpenAlexW2996536951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.