Evidence map›Paper›PMID 31853730›Full record

ArticleNeurotoxicity research2020

Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities.

Wildson Max Barbosa da Silva, Solange de Oliveira Pinheiro, Daniela Ribeiro Alves, Jane Eire Silva Alencar de Menezes, Francisco Ernani Alves Magalhães, Francisca Crislândia Oliveira Silva, Jacilene Silva, Emmanuel Silva Marinho, Selene Maia de Morais

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Metallo-herb complexes as emerging therapeutics: chemistry, synthesis approaches, and pharmacological insights.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wildson Max Barbosa da SilvaGraduate Program in Biotechnology, Laboratory of Chemistry of Natural Products (LQPN), Ceará State University, Fortaleza, Ceará, Brazil.
Solange de Oliveira PinheiroLaboratory of Inorganic Chemistry (LQUIN), Ceará State University, Fortaleza, Ceará, Brazil.
Daniela Ribeiro AlvesVeterinarian Sciences Post Graduation Program, Ceará State University, Fortaleza, Ceará, Brazil.
Jane Eire Silva Alencar de MenezesUndergraduate Program in Natural Sciences, Center for Science and Technology, State University of Ceará, Fortaleza, Brazil.
Francisco Ernani Alves MagalhãesLaboratory of Bioprospecting of Natural Products and Biotechnology (LBPNB), Ceará State University, Tauá, Ceará, Brazil.
Francisca Crislândia Oliveira SilvaUndergraduate Program in Natural Sciences, Center for Science and Technology, State University of Ceará, Fortaleza, Brazil.
Jacilene SilvaDepartment of Chemistry, Ceará State University, Limoeiro do Norte, Ceará, Brazil.
Emmanuel Silva MarinhoDepartment of Chemistry, Ceará State University, Limoeiro do Norte, Ceará, Brazil.
Selene Maia de MoraisGraduate Program in Biotechnology, Laboratory of Chemistry of Natural Products (LQPN), Ceará State University, Fortaleza, Ceará, Brazil. selenemaiademorais@gmail.com.
Universidade Estadual do Ceará · BR

Funding

Call 01/2017- Programa for SUS-PPSUS-Funcap-Decit/ACTIE/MS- CNPq Ref. Proc. No. 3781047/2017, Agreement 837577/2016
6 · The paper itself

Abstract

The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin coordination complexes with the metal ions Cu

Indexed as

Computer SimulationAnimalsAnti-Anxiety AgentsAntioxidantsCholinesterase InhibitorsCoordination ComplexesDrug Evaluation, PreclinicalIron CompoundsLocomotionMolecular Docking SimulationProtein Structure, SecondaryQuercetinZebrafishAnti-Anxiety AgentsAntioxidantsCholinesterase InhibitorsCoordination ComplexesIron CompoundsQuercetinAlzheimer’s diseaseCoordination compoundsFlavonoids

Identifiers

PMID31853730
OpenAlexW2994802064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.