Evidence map›Paper›PMID 31853687›Full record

Observational studyEuropean journal of pediatrics2020

Hypoxic-ischemic enterocolitis: a proposal of a new terminology for early NEC or NEC-like disease in preterm infants, a single-center prospective observational study.

Ozge Surmeli Onay, Ayse Korkmaz, Sule Yigit, Murat Yurdakok

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ozge Surmeli OnaySection of Neonatology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey. ozgeonay79@gmail.com.ORCID http://orcid.org/0000-0002-7658-3594
Ayse KorkmazSection of Neonatology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Sule YigitSection of Neonatology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Murat YurdakokSection of Neonatology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Hacettepe University · TR

Funding

Hacettepe Üniversitesi Funding Sources: This study was supported by Hacettepe University (Research Grant No: 011 D04 101008)
6 · The paper itself

Abstract

We aimed to investigate the role of hypoxia-ischemia in the pathophysiology of early NEC/NEC like disease (ENEC) and classic NEC/NEC like disease (CNEC) in preterm infants. In this pilot study, preterm infants who developed the clinical symptoms and signs of NEC/NEC like disease were divided into two groups as early (≤ 7 days, ENEC) or late (> 7 days, CNEC) groups. Beside clinical variables, serum L-lactate, endothelin-1 (ET-1), platelet activating factor (PAF), and intestinal fatty acid binding protein (I-FABP) levels were measured from umbilical/peripheric venous blood in the first hour of life and during the clinical presentation in all groups. A total of 86 preterm infants were enrolled in the study. In the ENEC group, the incidences of fetal umbilical artery Doppler velocimetry abnormalities, IUGR, and delayed passage of first meconium were higher. In addition, mean levels of L-lactate, ET-1, PAF, and I-FABP were higher in the first hour of life.Conclusion: Our study firstly showed that the dominant pathophysiological factor of ENEC is prenatal hypoxic-ischemic event where intestinal injury and inflammation begin in-utero and become clinically apparent in the first week of life. Therefore, we propose a new term "Hypoxic-Ischemic Enterocolitis (HIEnt)" for the definition of ENEC in preterm infants with prenatal hemodynamic disturbances and IUGR. This new sight can provide individualized preventive and therapeutic strategies for preterm infants.What is Known:• The pathophysiology of early necrotizing enterocolitis (NEC) or NEC-like disease which is seen in the first week of life seems different than classic necrotizing enterocolitis (CNEC) which is always seen after the first week of life.What is New:• This study suggests that perinatal hypoxic-ischemic process with inflammation is the point of origin of fetal intestinal injury leading to ENEC.• We propose a new term "Hypoxic-Ischemic Enterocolitis (HIEnt)" for the definition and differentiation of this unique clinical entity.

Indexed as

BiomarkersCase-Control StudiesEnterocolitis, NecrotizingFatty Acid-Binding ProteinsFemaleFetal DiseasesHumansHypoxiaInfant, Extremely Low Birth WeightInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLactic AcidMalePilot ProjectsProspective StudiesBiomarkersFABP2 protein, humanFatty Acid-Binding ProteinsLactic AcidET-1I-FABPLactateNecrotizing enterocolitisPAF

Identifiers

PMID31853687
OpenAlexW2996224579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.