Evidence map›Paper›PMID 31853656›Full record

ReviewCurrent treatment options in oncology2019

Opioid-Induced Constipation in Oncological Patients: New Strategies of Management.

Ricard Mesía, Juan Antonio Virizuela Echaburu, Jose Gómez, Tamara Sauri, Gloria Serrano, Eduardo Pujol

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current treatment options in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. The efficacy of acupressure in managing opioid-induced constipation in patients with cancer: A single-blind randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial
  5. Dose-dependent association of naldemedine and magnesium oxide in the management of opioid-induced constipation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational
  6. Review
  7. Article
  8. Article
  9. Observational
  10. Opioid-induced Constipation: Old and New Concepts in Diagnosis and Treatment.Journal of neurogastroenterology and motility · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Risk factors for opioid-induced constipation in cancer patients: a single-institution, retrospective analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Naldemedine: A New Option for OIBD.Journal of pain research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Ricard MesíaServicio de Oncología Médica, Instituto Catalán de Oncología, Badalona, Spain.
Juan Antonio Virizuela EchaburuServicio de Oncología Médica, Hospital General Universitario Virgen Macarena, Seville, Spain. javirizuelae@seom.org.
Jose GómezHospital la Fe, Valencia, Spain.
Tamara SauriHospital Clinic de Barcelona, Barcelona, Spain.
Gloria SerranoHospital Infanta Leonor, Madrid, Spain.
Eduardo PujolHospital Clínico Lozano Blesa, Zaragoza, Spain.
Hospital Clínic de Barcelona · ESHospital Clínico Universitario Lozano Blesa · ESHospital Universitario Infanta Leonor · ESHospital Universitario Virgen Macarena · ESInstitut Català d'Ornitologia · ESLeitat Technological Center · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

opinion statementCancer-associated pain has traditionally been treated with opioid analgesics, often in escalating doses. Opioid-induced constipation (OIC) is a common problem associated with chronic use of opioid analgesics. Typical treatment strategies to alleviate constipation are based on dietary changes, exercise, and laxatives. However, laxatives have a nonspecific action and do not target underlying mechanisms of OIC. This article will review prevalent, clinical presentation and recommendations for the treatment of OIC. An independent literature search was carried out by the authors. We reviewed the literature for randomized controlled trials that studied the efficacy of laxatives, naloxone, and naloxegol in treating OIC. Newer strategies addressing the causal pathophysiology of OIC are needed for a more effective assessment and management of OIC. Finally, traditional recommended therapies are appraised and compared with the latest pharmacological developments. Future research should address whether naloxegol is more efficacious by its comparison directly with first-line treatments, including laxatives.

Indexed as

Analgesics, OpioidCancer PainDisease ManagementHumansNeoplasmsOpioid-Induced ConstipationPain ManagementAnalgesics, OpioidCancerLaxativesNaloxegolOpioid analgesicsOpioid-induced constipationPain

Identifiers

PMID31853656
PMCPMC6920224
OpenAlexW2996312737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.