Evidence map›Paper›PMID 31853516›Full record

ArticleACS applied bio materials2019

Surfactant-Stripped Pheophytin Micelles for Multimodal Tumor Imaging and Photodynamic Therapy.

Dana Moukheiber, Upendra Chitgupi, Kevin A Carter, Dandan Luo, Boyang Sun, Shreya Goel, Carolina A Ferreira, Jonathan W Engle, Depeng Wang, Jumin Geng and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Dana MoukheiberDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Upendra ChitgupiDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Kevin A CarterDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Dandan LuoDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Boyang SunDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Shreya GoelDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Carolina A FerreiraDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Jonathan W EngleDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Depeng WangDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Jumin GengDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Yumiao ZhangDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Jun XiaDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Weibo CaiDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID 0000-0003-4641-0833
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.ORCID 0000-0002-9052-884X
University at Buffalo, State University of New York · USUniversity of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Light-Triggered Drug Release in Primed Pancreatic TumorsR01EB017270 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2021
$3.5M
Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NIBIB NIH HHS R01 EB017270NIH HHS DP5 OD017898
6 · The paper itself

Abstract

Porphyrin-based nanomaterials can inherently integrate multiple contrast imaging functionalities with phototherapeutic capabilities. We dispersed pheophytin (Pheo) into Pluronic F127 and carried out low-temperature surfactant-stripping to remove the bulk surfactant. Surfactant-stripped Pheo (ss-Pheo) micelles exhibited a similar size, but higher near-infrared fluorescence, compared to two other nanomaterials also with high porphyrin density (surfactant-stripped chlorophyll micelles and porphysomes). Singlet oxygen generation, which was higher for ss-Pheo, enabled photodynamic therapy (PDT). ss-Pheo provided contrast for photoacoustic and fluorescence imaging, and following seamless labeling with

Indexed as

fluorescencemicellespheophytinphotoacousticphotodynamic therapypositron emission tomography

Identifiers

PMID31853516
PMCPMC6919654
OpenAlexW2906631717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.