Evidence map›Paper›PMID 31853455›Full record

ArticleHypoxia (Auckland, N.Z.)2019

An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23.

Daisheng Song, Wei Guan, Lea M Coon, Aref Al-Kali, Jennifer L Oliveira, Frank S Lee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypoxia (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Daisheng SongDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Wei GuanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lea M CoonHematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Aref Al-KaliDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Jennifer L OliveiraHematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-7082-9920
Frank S LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-2511-1834
Mayo Clinic · USUniversity of Pennsylvania · USUnion Hospital · CN

Funding

Control of Erythropoiesis by the Oxygen Sensor PHD2R01DK104796 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEE, FRANK S · 2015 to 2019
$1.8M
High Altitude Adaptation: A Model for Chronic HypoxiaR33HL120751 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LEE, FRANK S · 2016 to 2018
$1.5M
NHLBI NIH HHS R33 HL120751NIDDK NIH HHS R01 DK104796
6 · The paper itself

Abstract

backgroundLoss of function mutations in the

resultsHere, we characterize an erythrocytosis-associated mutation in the zinc finger, K55N, that abolishes interaction with p23. We provide evidence that the affected residue, Lys-55, interacts with Asp-152 of p23. We also present results that indicate that PHD2 Arg-32 interacts with p23 Glu-160.

conclusionThese studies not only reinforce the importance of the PHD2 zinc finger in the control of erythropoiesis, but also lead to a model in which a peptide motif in p23 binds in a specific orientation to a predicted groove in the zinc finger of PHD2.

Indexed as

EGLN1erythropoietinhypoxia inducible factorpolycythemiaprolyl hydroxylase domain protein 2

Identifiers

PMID31853455
PMCPMC6916684
OpenAlexW2994913012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.