ArticleBiomedical optics express2019
Hybrid light-sheet and light-field microscope for high resolution and large volume neuroimaging.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Fast 3D dynamic visualization of porcine spermatozoa by using high-resolution wavefront coding light sheet microscopy and machine learning.Scientific reports · 2026Article
- Accurate neuron segmentation method for one-photon calcium imaging videos combining convolutional neural networks and clustering.Communications biology · 2024Article
- Efficient high-resolution fluorescence projection imaging over an extended depth of field through optical hardware and deep learning optimizations.Biomedical optics express · 2024Article
- Model-Based Explainable Deep Learning for Light-Field Microscopy Imaging.IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · 2024Article
- Volumetric light sheet imaging with adaptive optics correction.Biomedical optics express · 2023Article
- Whole-brain imaging of freely-moving zebrafish.Frontiers in neuroscience · 2023Review
- A fully water coupled oblique light-sheet microscope.Scientific reports · 2022Article
- Light-Field Microscopy for Optical Imaging of Neuronal Activity: When Model-Based Methods Meet Data-Driven Approaches.IEEE signal processing magazine · 2022Article
- Background inhibited and speed-loss-free volumetric imagingFrontiers in neuroscience · 2022Article
- High-resolution light-field microscopy with patterned illumination.Biomedical optics express · 2021Article
- Imaging volumetric dynamics at high speed in mouse and zebrafish brain with confocal light field microscopy.Nature biotechnology · 2021Article
- Decontaminate Traces From Fluorescence Calcium Imaging Videos Using Targeted Non-negative Matrix Factorization.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Large scale simultaneous recording of fast patterns of neural activity remains challenging. Volumetric imaging modalities such as scanning-beam light-sheet microscopy (LSM) and wide-field light-field microscopy (WFLFM) fall short of the goal due to their complex calibration procedure, low spatial resolution, or high-photobleaching. Here, we demonstrate a hybrid light-sheet light-field microscopy (LSLFM) modality that yields high spatial resolution with simplified alignment of the imaging plane and the excitation plane. This new modality combines the selective excitation of light-sheet illumination with volumetric light-field imaging. This modality overcomes the current limitations of the scanning-beam LSM and WFLFM implementations. Compared with LSM, LSLFM captures volumetric data at a frame rate 50× lower than the rate of LSM and requires no dynamic calibration. Compared with WFLFM, LSLFM produces moderate improvements in spatial resolutions, 10 times improvement in the contrast when imaging fluorescent beads, and 3.2× the signal-to-noise ratio in the detection of neural activity when imaging live zebrafish expressing a genetically encoded calcium sensor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.