ArticleBiomedical optics express2019
Dual-mode emission and transmission microscopy for virtual histochemistry using hematoxylin- and eosin-stained tissue sections.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Virtual Evaluation of Hematoxylin & Eosin via Digital Pathology Survey (VEED) Project: Results from a Non-Inferiority Study of a Tabs-Based Staining Method.Diagnostics (Basel, Switzerland) · 2026Article
- Whole-slide mapping of tumor tissue fiber architecture via computational scattered light imaging.Biomedical optics express · 2026Article
- Slide-free, point-of-care imaging of core needle biopsies for rapid histologic assessment.Biomedical optics express · 2026Article
- Fibre orientations in collagen-containing tissues revealed with computational scattered light imaging and polarimetric second harmonic generation microscopy.Scientific reports · 2025Article
- Current Landscape of Advanced Imaging Tools for Pathology Diagnostics.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024Review
- Highly sensitive and specific resonance Rayleigh scattering detection of esophageal cancer cells via dual-aptamer target binding strategy.Mikrochimica acta · 2023Article
- Mapping variation of extracellular matrix in human keloid scar by label-free multiphoton imaging and machine learning.Journal of biomedical optics · 2023Article
- Improving quantification of renal fibrosis usingProceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Differential diagnosis of thyroid nodule capsules using random forest guided selection of image features.Scientific reports · 2022Article
- Unsupervised super-resolution reconstruction of hyperspectral histology images for whole-slide imaging.Journal of biomedical optics · 2022Article
- Automatic detection of head and neck squamous cell carcinoma on histologic slides using hyperspectral microscopic imaging.Journal of biomedical optics · 2022Article
- Automated Structural Analysis and Quantitative Characterization of Scar Tissue Using Machine Learning.Diagnostics (Basel, Switzerland) · 2022Article
- Machine-Learning-Based Evaluation of Intratumoral Heterogeneity and Tumor-Stroma Interface for Clinical Guidance.The American journal of pathology · 2021Review
- Real-time polarization microscopy of fibrillar collagen in histopathology.Scientific reports · 2021Article
- Tumor collagen framework from bright-field histology images predicts overall survival of breast carcinoma patients.Scientific reports · 2021Article
- Beyond brightfield: a possible future of slide scanners.BioTechniques · 2021Article
- Hyperspectral and multispectral imaging in digital and computational pathology: a systematic review [Invited].Biomedical optics express · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
In the clinical practice of pathology, trichrome stains are commonly used to highlight collagen and to help evaluate fibrosis. Such stains do delineate collagen deposits but are not molecularly specific and can suffer from staining inconsistencies. Moreover, performing histochemical stain evaluation requires the preparation of additional sections beyond the original hematoxylin- and eosin-stained slides, as well as additional staining steps, which together add cost, time, and workflow complications. We have developed a new microscopy approach, termed DUET (DUal-mode Emission and Transmission) that can be used to extract signals that would typically require special stains or advanced optical methods. Our preliminary analysis demonstrates the potential of using the resulting signals to generate virtual histochemical images that resemble trichrome-stained slides and can support clinical evaluation. We demonstrate advantages of this approach over images acquired from conventional trichrome-stained slides and compare them with images created using second harmonic generation microscopy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.