ArticleBiomedical optics express2019
Detection of heavy metal ions using whispering gallery mode lasing in functionalized liquid crystal microdroplets.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Luminescent Nanocomposites of Liquid Crystals and Carbon Dots in Microfluidic Channels: Effects of Walls, Dynamics, and Bioactive Additive.Nanomaterials (Basel, Switzerland) · 2026Article
- Predicting Liquid Crystal Behavior with Artificial Neural Networks.Micromachines · 2025Article
- High-Q WGM microcavity-based optofluidic sensor technologies for biological analysis.Biomicrofluidics · 2024Review
- Highly sensitive and label-free detection of biotin using a liquid crystal-based optofluidic biosensor.Biomedical optics express · 2023Article
- Review
- Review
- Liquid Crystal Biosensors: Principles, Structure and Applications.Biosensors · 2022Review
- State-of-the-Art Development in Liquid Crystal Biochemical Sensors.Biosensors · 2022Review
- Review
- Applications of Microfluidics in Liquid Crystal-Based Biosensors.Biosensors · 2021Review
- Uptake and Distribution Characteristic and Health Risk Assessment of Heavy Metal(loid)s in Platycodon Grandiflorum (Jacq.) A.DC. with Growth from a Medicinal Herb Garden of Xi'an, China.Biological trace element research · 2021Article
- Liquid crystal-amplified optofluidic biosensor for ultra-highly sensitive and stable protein assay.PhotoniX · 2021Article
- Label-Free Optical Resonator-Based Biosensors.Sensors (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate a detection method for heavy metal (HM) ions based on whispering gallery mode (WGM) lasing in a liquid crystal (LC) microdroplet biosensor. By doping with stearic acid, nematic LC 4-cyano-4'-pentylbiphenyl (5CB) microdroplets are biochemically functionalized and used as both optical microresonators and sensing elements. Typical WGM lasing emission is observed in stearic acid-doped 5CB microdroplets under a pulse laser pump. Our results show that quantitative spectral shift of WGMs can serve as a real-time indicator of the adsorption of HM ions on the microdroplet surface. The detection limit of our sensor is as low as 40 pM for Cu(II) ions, six orders of magnitude better than the exposure threshold defined by the World Health Organization. Furthermore, this sensing system has an ability to discriminate between heavy and light metal ions. We believe that this novel biosensor has great application potential for environmental monitoring and drinking water quality testing.
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Registered trials
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