Evidence map›Paper›PMID 31853373›Full record

ArticleAnimal cells and systems2019

Dexmedetomidine ameliorates memory impairment in sleep-deprived mice.

Lakkyong Hwang, Il-Gyu Ko, Jun-Jang Jin, Sang-Hoon Kim, Chang-Ju Kim, Boksoon Chang, Jeong Ho Rho, Eun-Jin Moon, Jae-Woo Yi

Open access · goldAbstract read
In one paragraph

Article in Animal cells and systems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. [Effects of Vitamin BSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
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  6. Myricetin prevents sleep deprivation-induced cognitive impairment and neuroinflammation in rat brainThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Article
  7. General anesthesia and sleep: like and unlike.Anesthesia and pain medicine · 2022
    Review
  8. Article
  9. Article
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  11. Article
  12. Review
  13. Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lakkyong HwangDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.ORCID 0000-0002-7916-3229
Il-Gyu KoDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.ORCID 0000-0003-2696-6869
Jun-Jang JinDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Sang-Hoon KimDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Chang-Ju KimDepartment of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Boksoon ChangDepartment of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Jeong Ho RhoDepartment of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Eun-Jin MoonDepartment of Anesthesiology and Pain Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Jae-Woo YiDepartment of Anesthesiology and Pain Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Kyung Hee University · KRKyung Hee University Hospital at Gangdong · KRGangdong University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The selective α2-adrenergic receptor agonist dexmedetomidine acts as an analgesic, sedative, and anesthetic adjuvant. The most common consequence of sleep deprivation is memory impairment. We investigated whether dexmedetomidine can counteract memory impairment caused by sleep deprivation and suppress the production of inflammatory factors. For inducing sleep deprivation, adult male mice were placed inside a water cage containing 15 platforms immersed in water up to 1 cm for 7 days. One day after sleep deprivation, dexmedetomidine at the respective dosage (5, 10, and 20 μg/kg) and α

Indexed as

dexmedetomidineinflammationmemory impairmentSleep deprivationα2-adrenoceptor agonist

Identifiers

PMID31853373
PMCPMC6913667
OpenAlexW2988826448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.