Evidence map›Paper›PMID 31853349›Full record

ArticleChemical science2019

Mitochondria-targeting fluorescent molecules for high efficiency cancer growth inhibition and imaging.

Hao Chen, Jing Wang, Xin Feng, Mark Zhu, Simon Hoffmann, Alex Hsu, Kun Qian, Daijuan Huang, Feng Zhao, Wei Liu and 2 more

Abstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
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  11. Recent Advances inMolecules (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hao ChenDepartment of Radiology , The First Hospital of Jilin University , Changchun , 130021 , China . Email: huimaozhanglinda@163.com.
Jing WangDepartment of Radiology , The First Hospital of Jilin University , Changchun , 130021 , China . Email: huimaozhanglinda@163.com.
Xin FengMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email: zcheng@stanford.edu.
Mark ZhuMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email: zcheng@stanford.edu.
Simon HoffmannMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email: zcheng@stanford.edu.
Alex HsuMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email: zcheng@stanford.edu.
Kun QianMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email: zcheng@stanford.edu.
Daijuan HuangMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email: zcheng@stanford.edu.
Feng ZhaoMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email: zcheng@stanford.edu.
Wei LiuDepartment of Radiology , The First Hospital of Jilin University , Changchun , 130021 , China . Email: huimaozhanglinda@163.com.
Huimao ZhangDepartment of Radiology , The First Hospital of Jilin University , Changchun , 130021 , China . Email: huimaozhanglinda@163.com.
Zhen ChengMolecular Imaging Program at Stanford (MIPS) , Bio-X Program , Department of Radiology , Canary Center at Stanford for Cancer Early Detection , Stanford University , California 94305-5344 , USA . Email: zcheng@stanford.edu.ORCID 0000-0001-8177-9463

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
NCI NIH HHS P30 CA124435
6 · The paper itself

Abstract

Fluorescent mitochondria-accumulating delocalized lipophilic cations (DLCs) for cancer therapy have drawn significant attention in the field of cancer theranostics. One of the most promising fluorescent DLCs, F16, can selectively trigger the apoptosis and necrosis of cancer cells, making it an attractive targeted theranostic drug candidate. However, it suffers from low clinical translation potential, largely due to its inefficient anti-cancer activity (IC

Identifiers

PMID31853349
PMCPMC6836573

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.