ArticleChemical science2019
Peptide-induced super-assembly of biocatalytic metal-organic frameworks for programmed enzyme cascades.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Enhancing Multi-Enzyme Cascade Activity in Metal-Organic Frameworks via Controlled Enzyme Encapsulation.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
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- Covalent-organic framework nanobionics for robust cytoprotection.Chemical science · 2024Article
- Facet-controlled assembly for organizing metal-organic framework particles into extended structures.iScience · 2023Review
- Opportunities and Challenges of Metal-Organic Framework Micro/Nano Reactors for Cascade Reactions.JACS Au · 2023Review
- Peptide-derived coordination frameworks for biomimetic and selective separation.Analytical and bioanalytical chemistry · 2023Review
- Site-Specific Antibody Assembly on Nanoparticles via a Versatile Coating Method for Improved Cell Targeting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Role of Molecular Modification and Protein Folding in the Nucleation and Growth of Protein-Metal-Organic Frameworks.Chemistry of materials : a publication of the American Chemical Society · 2022Article
- Biocatalytic cascades and intercommunicated biocatalytic cascades in microcapsule systems.Chemical science · 2022Article
- Hierarchically encapsulating enzymes with multi-shelled metal-organic frameworks for tandem biocatalytic reactions.Nature communications · 2022Article
- Recent Progress of Metal-Organic Framework-Based Photodynamic Therapy for Cancer Treatment.International journal of nanomedicine · 2022Review
- Stable DNA Aptamer-Metal-Organic Framework as Horseradish Peroxidase Mimic for Ultra-Sensitive Detection of Carcinoembryonic Antigen in Serum.Gels (Basel, Switzerland) · 2021Article
- Evaluation of temperature, pH and nutrient conditions in bacterial growth and extracellular hydrolytic activities of two Alicyclobacillus spp. strains.Archives of microbiology · 2021Article
- A DNA nanopillar as a scaffold to regulate the ratio and distance of mimic enzymes for an efficient cascade catalytic platform.Chemical science · 2020Article
- Metal-Organic Frameworks for Enzyme Immobilization: Beyond Host Matrix Materials.ACS central science · 2020Review
- Article
- Efficient polymerase chain reaction assisted by metal-organic frameworks.Chemical science · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the promise of metal-organic frameworks (MOFs) as functional matrices for enzyme stabilization, the development of a stimulus-responsive approach to induce a multi-enzyme cascade reaction in MOFs remains a critical challenge. Here, a novel method using peptide-induced super-assembly of MOFs is developed for programmed enzyme cascade reactions on demand. The super-assembled MOF particles containing different enzymes show remarkable 7.3-fold and 4.4-fold catalytic activity enhancements for the two-enzyme and three-enzyme cascade reactions, respectively, as compared with the unassembled MOF nanoparticles. Further digestion of the coiled-coil forming peptides on the MOF surfaces leads to the MOF superstructure disassembly and the programmed enzyme cascade reaction being "switched-off". Research on these stimuli-responsive materials with controllable and predictable biocatalytic functions/properties provide a concept to facilitate the fabrication of next-generation smart materials based on precision chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.