Evidence map›Paper›PMID 31853258›Full record

ArticleObstetric medicine2019

Therapeutic challenges in the treatment of systemic inflammatory disease in pregnancy.

Jared S Fredrickson, Jason R Kolfenbach, Jennifer L Holmes, Jennifer N Cathcart, Anne M Lynch, Alan G Palestine

Open access · greenAbstract read
In one paragraph

Article in Obstetric medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jared S FredricksonDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Jason R KolfenbachDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Jennifer L HolmesDepartment of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA.
Jennifer N CathcartDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Anne M LynchDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Alan G PalestineDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID https://orcid.org/0000-0001-6361-6767
University of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGranulomatosis with polyangiitis and Behçet's disease can occur during pregnancy and may be treated by ophthalmologists, rheumatologists, and obstetricians. We hypothesized that specialty training would affect the way physicians selected therapy.

methodsUsing an online questionnaire, 209 uveitis specialists, 853 rheumatologists, and 2500 obstetricians were surveyed. Respondents were given clinical vignettes containing a female patient who was contemplating pregnancy or in the first trimester and was diagnosed with granulomatosis with polyangiitis or Behçet's disease.

resultsIn the patient with granulomatosis with polyangiitis, therapy choice between specialties for biologic versus non-biologic systemic immunosuppressive medications was significantly different for both the non-pregnant and pregnant patient (p < 0.00001, p < 0.00003). In the non-pregnant patient diagnosed with Behçet's disease, the therapy choice between biologic versus non-biologic medications was also significantly different (p < 0.0003).

conclusionsSpecialty training affects how physicians manage granulomatosis with polyangiitis and Behçet's disease. Development of inter-specialty guidelines and treatment plans may improve outcomes, communication, and patient care.

Indexed as

Behçet’s diseaseGranulomatosis with polyangiitisimmunosuppressionpregnancy

Identifiers

PMID31853258
PMCPMC6909302
OpenAlexW2909782817

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.